Age-related Differences in Response to Pituitary Stimulation Tests

NCT ID: NCT04572139

Last Updated: 2025-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-23

Study Completion Date

2024-12-31

Brief Summary

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The purpose of this study to age-related differences to the response of a combined pituitary stimulation test with TRH, LHRH and ACTH.

Detailed Description

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Participants will be recruited in three different age intervals: 18-45 years, 55-80 years and 80+ years. These participants will all undergo the same stimulation test with 0.1 mg LHRH, 0.2 mg TRH, and 0.25 mg ACTH (Synachten). The tests will be perfomed at the same time of day for all particpants (between 08:15 and 08:45) and participants will be fasting for the test. Blood samples will be taken just before and at 10, 20, 30, 45, 60, 90 and 120 minutes following the stimulation test. Serum from blood samples will be stored at -20 degrees until analysis.

Conditions

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Pituitary Aging

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Young participants

18-45 years old

Pituitary stimulation test

Intervention Type DIAGNOSTIC_TEST

Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH

Old participants

55-80 years old

Pituitary stimulation test

Intervention Type DIAGNOSTIC_TEST

Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH

Oldest old participants

over 80 years old

Pituitary stimulation test

Intervention Type DIAGNOSTIC_TEST

Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH

Interventions

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Pituitary stimulation test

Pituitary stimulation with 0.1 mg LHRH, 0.2 mg TRH and 0.25 mg ACTH

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Ages between 18-45 or above 55.
* Healthy Volunteers

Exclusion Criteria

* Medication or conditions affecting pituitary response (such as hormonal birth control, steriod use, thyroid disorders)
* Pregnancy or birth within the last year
* inability to give informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Aalborg University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Johannes Riis

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Geriatric Medicine, Aalborg University Hospital

Aalborg, Northen Jutland, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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N-20200008

Identifier Type: -

Identifier Source: org_study_id

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