Posttraumatic Hypopituitarism - Incidence, Predictors and Test Validity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

463 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-10-31

Study Completion Date

2014-12-31

Brief Summary

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The purpose of the study is to estimate the incidence of posttraumatic hypopituitarism, and to identify predisposing factors in order to establish a rational responsible socioeconomic screening program.

Detailed Description

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Conditions

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Traumatic Brain Injury Hypopituitarism

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* International Classification of Diseases (ICD) 10 code S06.0-06.9
* Age 18 - 65 years at time of traumatic brain injury
* Duration of hospitalization \> 24 hours.

Exclusion Criteria

* Known pituitary disease
* Clinically significant liver or renal disease
* Breast-feeding
* Pregnancy
* Alcohol or drug abuse

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Marianne Christina Klose

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ulla Feldt-Rasmussen, MD

Role: STUDY_CHAIR

Dept of Endocrinology, Rigshospitalet

References

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Klose M, Stochholm K, Janukonyte J, Christensen LL, Cohen AS, Wagner A, Laurberg P, Christiansen JS, Andersen M, Feldt-Rasmussen U. Patient reported outcome in posttraumatic pituitary deficiency: results from The Danish National Study on posttraumatic hypopituitarism. Eur J Endocrinol. 2015 Jun;172(6):753-62. doi: 10.1530/EJE-14-1069. Epub 2015 Mar 12.

Reference Type DERIVED

PMID: 25766045 (View on PubMed)

Other Identifiers

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H-B-2008-122

Identifier Type: -

Identifier Source: org_study_id