Effect of Heat Stress on Global LV Function in Anesthetized Humans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-09

Study Completion Date

2019-12-06

Brief Summary

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Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.

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Detailed Description

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Conditions

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Hyperthermia Cardiac Functional Disturbances During Surgery

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Interventions

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Transesophageal Echocardiography

Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* any patient presenting for hyperthermic intraperitoneal chemotherapy.

Exclusion Criteria

* Subjects less than 18 years old.
* pregnant women
* prisoners,
* institutionalized individuals
* Any patient with known contraindication to Transesophageal echocardiography.
* Patients with known cardiac dysfunction prior to screening will be excluded.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No