Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings

NCT ID: NCT04520841

Last Updated: 2022-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-01

Study Completion Date

2024-06-01

Brief Summary

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Negative pressure dressings are currently widely used in wound management. Their use is gradually being extended to surgical scars. However, studies demonstrating a clear benefit are rare, particularly in terms of postoperative discharge, the need for surgical revision due to prolonged oozing and cost.

The aim of this study is to evaluate the benefit of such a device in post-operative revision prosthesis surgery (hip and knee), as well as lower limb amputations.

Detailed Description

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Conditions

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Arthroplasty Complications Amputation Prosthesis-Related Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Standard dry dressing in total hip or knee arthroplasty

Standard dressing in total hip or knee arthroplasty surgery revision: a dry sterile dressing is applied on the surgical wound at the end of surgery

Group Type ACTIVE_COMPARATOR

Dry dressing

Intervention Type DEVICE

A standard dry sterile dressingwith non-adherent absorbent pad is applied on the surgical wound at the end of surgery

Prevena in total hip or knee arthroplasty

Prevena incision management system in total hip or knee arthroplastsy surgery revision:

The Prevena incision management system is applied on the surgical wound at the end of surgery

Group Type EXPERIMENTAL

Prevena TM

Intervention Type DEVICE

A Prevena Plus DuoTM Dressing Kit (KCI) is applied on the surgical wound at the end of surgery.

Standard dry dressing in lower limb amputation

Standard dressing in lower limb amputation: a dry sterile dressing is applied on the surgical wound at the end of surgery

Group Type ACTIVE_COMPARATOR

Dry dressing

Intervention Type DEVICE

A standard dry sterile dressingwith non-adherent absorbent pad is applied on the surgical wound at the end of surgery

Prevena in lower limb amputation

Prevena incision management system in lower limb amputation:

The Prevena incision management system is applied on the surgical wound at the end of surgery

Group Type EXPERIMENTAL

Prevena TM

Intervention Type DEVICE

A Prevena Plus DuoTM Dressing Kit (KCI) is applied on the surgical wound at the end of surgery.

Interventions

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Prevena TM

A Prevena Plus DuoTM Dressing Kit (KCI) is applied on the surgical wound at the end of surgery.

Intervention Type DEVICE

Dry dressing

A standard dry sterile dressingwith non-adherent absorbent pad is applied on the surgical wound at the end of surgery

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent
* Age ≥ 18 years old
* Planned Surgery :

1. revision of a hip or knee prosthesis, in 1 or 2 stages, at explantation and/or reimplantation, where
2. elective amputation of a lower limb (transmetatarsal, trans-tibial (Burgess) or trans-femoral (Gritti-Stokes) level (nb: patients for whom amputation of both lower limbs is planned will be excluded)

Exclusion Criteria

* Known allergy to dry dressings
* Patient already included in another clinical trial
* Inability to discern and/or inability to follow study procedures
* Known allergy to silver or another component of the system Prevena™
* Amputation for tumor pathology
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Lausanne Hospitals

OTHER

Sponsor Role lead

Responsible Party

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Sylvain Steinmetz

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sylvain Steinmetz, MD

Role: PRINCIPAL_INVESTIGATOR

Lausanne University Hospital (Switzerland)

Locations

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Lausanne University Hospital

Lausanne, Canton of Vaud, Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Sylvain Steinmetz, MD

Role: CONTACT

+41 (0)21 314 27 89

Diane Wernly, MD

Role: CONTACT

+41 (0)76 581 49 73

Facility Contacts

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Sylvain Steinmetz, MD

Role: primary

Other Identifiers

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2020-00321

Identifier Type: -

Identifier Source: org_study_id

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