Relationship Between Pre-induction Electroencephalogram Pattern of Adult Patients and Their Sensitivity to Propofol

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-09

Study Completion Date

2022-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. However, It is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. If there is a specific pattern in EEG prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. The study is to find a relationship between the pre-induction EEG pattern of adult patients and their sensitivity to propofol.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Dose-response Curves Between Propofol and Intraoperative Electroencephalographic Patterns

NCT04345926

Propofol Overdose EEG

COMPLETED PHASE4

EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

NCT01543633

Brain Activity Under Sedation

COMPLETED NA

Application of the Propofol Precise Infusion Model

NCT05158426

Propofol Overdose of Undetermined Intent

COMPLETED

EEG Analysis During Light Propofol Sedation

NCT03362775

Electroencephalography

UNKNOWN PHASE1

Effect of Depth of Total Intravenous Anesthesia Using Propofol on Postoperative Cognitive Dysfunction

NCT01708837

Cognition Disorders

UNKNOWN PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Propofol Overdose of Undetermined Intent

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pre EEG group

This cohort includes all participants in this study. EEG sensor will be attached to the patient's forehead before induction of anesthesia. Patterns of EEG and data will be obtained

Propofol

Intervention Type DRUG

The dose of propofol required for loss of consciousness and the total induction dose of propofol will be recorded for every patients.

EEG monitoring

Intervention Type DEVICE

The processed EEG spectrogram and indices, such as patient status index, 95% spectral edge frequency, and suppression ratio, will be obtained from Sedline monitoring device. The raw pre-induction EEG will be extracted from Sedline at the end of induction and it will be analyzed by an external software to calculate the mean frequency, frequency band power and its distribution.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Propofol

The dose of propofol required for loss of consciousness and the total induction dose of propofol will be recorded for every patients.

Intervention Type DRUG

EEG monitoring

The processed EEG spectrogram and indices, such as patient status index, 95% spectral edge frequency, and suppression ratio, will be obtained from Sedline monitoring device. The raw pre-induction EEG will be extracted from Sedline at the end of induction and it will be analyzed by an external software to calculate the mean frequency, frequency band power and its distribution.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients undergoing general anesthesia

Exclusion Criteria

* Patients undergoing cardiac or brain surgery
* Patients with neurological deficit or impaired communication (Glasgow Coma Scale \< 15)
* Unstable vital sign (cardiogenic, hemorrhagic, septic shock)
* Patients with eclampsia
* Patients who administered preoperative anxiolytics
* Patients who do not require intubation
* Patients who are considered unsuitable for the study

Minimum Eligible Age

20 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No