Resolvin D1 Levels in Patients With Periodontitis

NCT ID: NCT04496570

Last Updated: 2020-08-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-31

Study Completion Date

2020-02-29

Brief Summary

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The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Detailed Description

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Conditions

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Periodontitis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Periodontitis patients

gingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment

Group Type ACTIVE_COMPARATOR

periodontal therapy

Intervention Type PROCEDURE

Non surgical periodontal therapy was performed to patients with peridontitis

Healthy individuals

gingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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periodontal therapy

Non surgical periodontal therapy was performed to patients with peridontitis

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Stage 3, Grade B and generalized periodontitis patients

Exclusion Criteria

* excessive forces;
* presence of systemic diseases
* administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
* having received non-surgical periodontal treatment within the past 6 months
* allergy or sensitivity to any drug,
* pregnancy, lactation
* current and former use of tobacco.
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ordu University

OTHER

Sponsor Role lead

Responsible Party

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Ceren Gökmenoğlu

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ordu University

Ordu, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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Ordu University Dental Faculty

Identifier Type: -

Identifier Source: org_study_id

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