Impact of Mode of Anesthesia on Ischemia Modified Albumin in Patients With Traumatic Brain Injury
NCT ID: NCT04490122
Last Updated: 2020-07-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
54 participants
OBSERVATIONAL
2020-07-23
2021-10-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
NCT05888389
The Effect of Mannitol Volume with Changes in Osmolarity in Traumatic Brain Injury
NCT06846307
Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest
NCT00441753
Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage
NCT03987139
The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery
NCT01204268
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The anesthesia will be induced with 2mcg/kg fentanyl and 2 mg/kg propofol. Muscle relaxation will be achieved with 0.5 mg/kg atracurium.
Anesthesia will be maintained with:
* Group I, isoflurane (mac\<1) mixed with oxygen 40% and fentanyl 1mcg/kg hourly.
* Group PD, propofol infusion(100-150mcg/kg/min) and dexmedetomedine 0.3mcg/kg /h.
Parameters will be assessed Preoperative period
* Ischemia modified albumin level from venous sample.
* Basal Systolic blood pressure, diastolic blood pressure. Mean arterial blood pressure, oxygen saturation, heart rate.
* GCS. Intraoperative period
* Systolic blood pressure, diastolic blood pressure. Mean arterial blood pressure, oxygen saturation, heart rate after intubation, 5,15,30,60,90min and after extubation.
* Need for resuscitation with vasoactive drugs.
* Brain relaxation score at dural opening and closure.
* ICP
* Intraoperative blood loss.
* Amount of fluid and blood transfusion. Postoperative period
* Ischemia modified albumin immediately postoperatively, after 6h and after 24 hours.
* Type of surgery.
* Duration of surgery.
* Extubation time.
* Recovery scores (Ramsay sedation score and modified Alderte score).
* GCS immediately postoperatively, after 6h, after 24h and after 48 hours.
* Total analgesic requirement during the first 24 hours.
* Need for ICU admission.
* Length of ICU stay.
* Complications.
* 28 day mortality.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Inhalational
will receive inhalational anesthesia
No interventions assigned to this group
Total intravenous
will receive total intravenous anesthesia with propofol infusion(100-150 mcg/kg/min) and dexmedetomedine 0.3mcg/kg/h.
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Isolated traumatic brain injury undergoing emergency craniotomy.
3. G.C.S more than 8.
4. ASA grade (I-III).
Exclusion Criteria
2. Poly trauma patient.
3. Coagulation disorder.
4. Drug( alcohol, opiods, tranquilizers) addiction.
5. Liver and kidney dysfunction.
6. Severe diseases such as severe hypertension, cardiovascular disease, malignant tumor, autoimmune disease, mental disorders.
7. Diabetes mellitus with poor blood glucose control.
8. Previous drug allergy.
9. Currently lactating.
18 Years
60 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Abd-elrahman hassan abd -elaziz
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Abd-elrahman hassan abd -elaziz
Minia University Hospital
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Ahmed K Mohamed, professor
Role: PRINCIPAL_INVESTIGATOR
Minia University
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Related Links
Access external resources that provide additional context or updates about the study.
Decompressive craniectomy and traumatic brain injury: a review.
Comparison of total intravenous anesthesia vs. inhalational anesthesia on brain relaxation, intracranial pressure, and hemodynamics in patients with acute subdural hematoma undergoing emergency craniotomy: a randomized control trial
The comparison of the effects of sevoflurane inhalation anesthesia and intravenous propofol anesthesia on oxidative stress in one lung ventilation.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
374
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.