The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation
NCT ID: NCT01489137
Last Updated: 2012-08-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2011-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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neurosurgery with fixation
remifentanil
According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during head fixation. And, For this allocation of dose of remifentanil the investigators use biased coin design up-and-down method.
For the first patient, the dose of remifentanil would be fixed at 5.5ng/ml which we predict as EC90. And, step size of dose is 0.5ng/ml.
Interventions
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remifentanil
According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during head fixation. And, For this allocation of dose of remifentanil the investigators use biased coin design up-and-down method.
For the first patient, the dose of remifentanil would be fixed at 5.5ng/ml which we predict as EC90. And, step size of dose is 0.5ng/ml.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* patients who agree to our study
Exclusion Criteria
* BMI\<16.0 or BMI\>30
* cardiovascular disease, pulmonary disease, renal disease
* alcoholic abuser or drug abuser
* patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system
* any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period
20 Years
65 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Jae-Hyon Bahk, MD, PhD
professor
Locations
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Seoul National University Hospital
Seoul, Seoul, South Korea
Countries
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References
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Lee JM, Bahk JH, Lim YJ, Lee J, Lim L. The EC90 of remifentanil for blunting cardiovascular responses to head fixation for neurosurgery under total intravenous anesthesia with propofol and remifentanil based on bispectral index monitoring: estimation with the biased coin up-and-down sequential method. BMC Anesthesiol. 2017 Oct 10;17(1):136. doi: 10.1186/s12871-017-0426-z.
Other Identifiers
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JHBahk_fixation_remifentanil
Identifier Type: -
Identifier Source: org_study_id