Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury

NCT ID: NCT05182619

Last Updated: 2022-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

EARLY_PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-04-01

Brief Summary

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the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler

Detailed Description

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Conditions

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Traumatic Brain Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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ultrasoung guided stellate block

stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow

Group Type ACTIVE_COMPARATOR

ultrasound-guided stellate ganglion block

Intervention Type PROCEDURE

under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side

nimodipine infusion

intravenous nimodipine will be given for enhancement of cerebral blood flow

Group Type ACTIVE_COMPARATOR

ultrasound-guided stellate ganglion block

Intervention Type PROCEDURE

under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side

Interventions

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ultrasound-guided stellate ganglion block

under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients more than 18 ys old with isolated head trauma and traumatic brain injury

Exclusion Criteria

* • Hemodynamic instability (mean ABP less than 70 mmHg)

* History of severe systemic disease including cardiopulmonary failure or hepatorenal failure
* Allergy to local anesthetics
* Coagulation disorders
* Abnormal neck structures disturbing normal anatomy as neck tumors
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Khaled Mohamed Abdelaal

assistant lecturer os anesthesia and intensive care

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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soh-Med-21-12-19

Identifier Type: -

Identifier Source: org_study_id

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