Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury
NCT ID: NCT02019810
Last Updated: 2015-08-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
20 participants
INTERVENTIONAL
2014-10-31
2016-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Noradrenaline alone
Treatment for 30 minutes with noradrenaline alone
Norepinephrine
Noradrenaline + dobutamine
Treatment with noradrenaline and dobutamine for 30 minutes
Dobutamine and norepinephrine
Interventions
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Norepinephrine
Dobutamine and norepinephrine
Eligibility Criteria
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Inclusion Criteria
* Closed traumatic brain injury
* Isolated TBI or polytraumatism
* Age between 18 and 65 years old
* Affiliated to a social security system
Exclusion Criteria
* Craniectomy
* High cerebral pressure without TBI
* No autoregulation
* Current hemorrhagic shock
* Chronic cardiac failure
* Chronic renal failure
* Hyperemia measured with transcranial doppler
* Short life expectancy
* Refused consent from the family
* Protected patients by the law
* Hypersensibility to one of the treatment or sulfites
18 Years
65 Years
ALL
No
Sponsors
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University Hospital, Grenoble
OTHER
Responsible Party
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Locations
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Grenoble University Hospital
Grenoble, , France
Countries
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Central Contacts
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Gilles Francony, MD
Role: CONTACT
Other Identifiers
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2013-003276-13
Identifier Type: -
Identifier Source: org_study_id
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