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The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

NCT ID: NCT01204268

Last Updated: 2010-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2011-10-31

Brief Summary

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The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Detailed Description

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The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Conditions

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Brain Ischemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Propofol group

Patients will receive the total intravenous anesthesia with propofol infusion during the surgery.

Group Type NO_INTERVENTION

No interventions assigned to this group

Sevo-C group

Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Group Type ACTIVE_COMPARATOR

Sevo continuous inhalation

Intervention Type PROCEDURE

Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Sevo-I group

Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.

Group Type EXPERIMENTAL

Sev-I group

Intervention Type PROCEDURE

Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.

Interventions

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Sev-I group

Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.

Intervention Type PROCEDURE

Sevo continuous inhalation

Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Intervention Type PROCEDURE

Other Intervention Names

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Sevoflurane preconditioning

Eligibility Criteria

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Inclusion Criteria

* Patient under intracranial aneurysm surgery.

Exclusion Criteria

* Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xijing Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xijing Hospital, Fourth Military Medical University

Principal Investigators

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Hailong Dong, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Xijing Hospital

Locations

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Xijing Hospital

Xi'an, Shaanxi, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Lize Xiong, MD,PhD

Role: primary

[email protected]
86-2984775337

Other Identifiers

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APC-BRAIN-2009

Identifier Type: -

Identifier Source: org_study_id