Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

124 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-10

Study Completion Date

2025-12-31

Brief Summary

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The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH). The main question\[s\] it aims to answer are:

• whether the two osmotic therapy, 20% mannitol and 10% hypertonic saline(HTS), under the same osmotic equivalent, has similar influence on the outcome of SAH patients?

Participants will be given proper treatment according to local expert consensus, including the choice of osmotic medicine. Investigators just record and analyse the data, compare mannitol group and HTS group to see if the outcome of latter is not worse than the former.

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Detailed Description

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Conditions

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Subarachnoid Hemorrhage, Traumatic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* ①age ≥18； ②aneurysmal subarachnoid hemorrhage; ③Hunt-Hess 3-5级

Exclusion Criteria

* previous cranial decompression surgery, cerebrospinal fluid leakage or drainage,

* bilateral pupils fixed or dilated,

* hemodynamic instability,

* hemoglobin \< 8g / L,

* serum osmolality \> 320 mOsm / L,

⑥ combined with severe organ dysfunction (cardiac, pulmonary, hepatic, renal and so on);

⑦ serious electrolyte disorders (serum sodium concentration \<125 mmol / L or \>170 mmol / L), and difficult to correct within limited time;

⑧ serious acid-base balance disorders, and difficult to correct within limited time;

⑨ use of mannitol or HSS within previous six hours;

⑩ being pregnant.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No