Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-01

Study Completion Date

2019-12-11

Brief Summary

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This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin (\[HbO2\]), deoxy-hemoglobin (\[Hb\]), the derived change in blood volume (\[tHb\]) and water concentration on the forehead of brain edema patients.

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Detailed Description

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Cerebral edema, as an acute head injury along with high intracranial pressure, has been of great interest over decades in clinical neurosurgery research. Dehydration therapy is a common clinical method to decrease intracranial pressure. This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin (\[HbO2\]), deoxy-hemoglobin (\[Hb\]), the derived change in blood volume (\[tHb\]) and water concentration on the forehead of brain edema patients. Then the investigators compared the changes process of multiple physiological parameters during different dehydration therapies.

Conditions

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Hemodynamic Instability Water on the Brain Intracranial Pressure Increase

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Mannitol injection

The participant receive mannitol injection to decrease intracranial pressure in the ward with optical probes on his/her forehead.

Group Type EXPERIMENTAL

Mannitol injection

Intervention Type PROCEDURE

Standard mannitol injection to decrease intracranial pressure of patients

Hypertonic saline injection

The participant receive hypertonic saline of specific concentration injection to decrease intracranial pressure in the ward with optical probes on his/her forehead.

Group Type EXPERIMENTAL

Hypertonic saline injection

Intervention Type PROCEDURE

Standard Hypertonic saline injection to decrease intracranial pressure of patients

Interventions

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Mannitol injection

Standard mannitol injection to decrease intracranial pressure of patients

Intervention Type PROCEDURE

Hypertonic saline injection

Standard Hypertonic saline injection to decrease intracranial pressure of patients

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

• Patients who had brain edema and need dehydration therapy to decrease intracranial pressure.

Exclusion Criteria

* AIDS, Active Hepatitis, Tuberculosis, Syphilis
* Patients who regularly take anticoagulants, antiplatelet drugs
* Anemia, thrombocytopenia
* Hemorrhagic disease like hemophilia

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No