The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
NCT ID: NCT04274777
Last Updated: 2020-02-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2019-09-21
2020-12-21
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
2. Age\>18yrs and age\<80yrs
3. Non-head abbreviated injury score \< 3
4. Did not undertake treatment before enrollment
5. Informed consent to participate in the study
Exclusion Criteria
2. Smoking history
3. Hemorrhagic or ischemic cerebrovascular disease occurred within six months
4. Other systemic diseases: uremia, cirrhosis, malignant tumor, etc
5. Patients with severe mental illness who are unable to communicate when diagnosed
6. Patients who refused follow-up
18 Years
80 Years
ALL
Yes
Sponsors
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Tang-Du Hospital
OTHER
Responsible Party
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Principal Investigators
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Yan Qu, M.D, Ph.D
Role: STUDY_CHAIR
Tang-Du Hospital
Shunnan Ge, M.D, Ph.D
Role: STUDY_DIRECTOR
Tang-Du Hospital
Wenxing Cui, M.D
Role: PRINCIPAL_INVESTIGATOR
Tang-Du Hospital
Locations
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Tandu Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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References
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Harhangi BS, Kompanje EJ, Leebeek FW, Maas AI. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien). 2008 Feb;150(2):165-75; discussion 175. doi: 10.1007/s00701-007-1475-8. Epub 2008 Jan 2.
Epstein DS, Mitra B, O'Reilly G, Rosenfeld JV, Cameron PA. Acute traumatic coagulopathy in the setting of isolated traumatic brain injury: a systematic review and meta-analysis. Injury. 2014 May;45(5):819-24. doi: 10.1016/j.injury.2014.01.011. Epub 2014 Jan 19.
Zehtabchi S, Soghoian S, Liu Y, Carmody K, Shah L, Whittaker B, Sinert R. The association of coagulopathy and traumatic brain injury in patients with isolated head injury. Resuscitation. 2008 Jan;76(1):52-6. doi: 10.1016/j.resuscitation.2007.06.024. Epub 2007 Aug 15.
Maeda T, Katayama Y, Kawamata T, Aoyama N, Mori T. Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. Acta Neurochir Suppl. 1997;70:102-5. doi: 10.1007/978-3-7091-6837-0_32.
Zhang J, Zhang F, Dong JF. Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury. Blood. 2018 May 3;131(18):2001-2006. doi: 10.1182/blood-2017-11-784108. Epub 2018 Mar 5.
Zhao Z, Wang M, Tian Y, Hilton T, Salsbery B, Zhou EZ, Wu X, Thiagarajan P, Boilard E, Li M, Zhang J, Dong JF. Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice. Blood. 2016 Jun 2;127(22):2763-72. doi: 10.1182/blood-2015-12-688838. Epub 2016 Mar 21.
Wu Y, Liu W, Zhou Y, Hilton T, Zhao Z, Liu W, Wang M, Yeon J, Houck K, Thiagarajan P, Zhang F, Shi FD, Wu X, Li M, Dong JF, Zhang J. von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury. Blood. 2018 Sep 6;132(10):1075-1084. doi: 10.1182/blood-2018-03-841932. Epub 2018 Jun 25.
Tian Y, Salsbery B, Wang M, Yuan H, Yang J, Zhao Z, Wu X, Zhang Y, Konkle BA, Thiagarajan P, Li M, Zhang J, Dong JF. Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury. Blood. 2015 Mar 26;125(13):2151-9. doi: 10.1182/blood-2014-09-598805. Epub 2015 Jan 27.
Zhou Y, Cai W, Zhao Z, Hilton T, Wang M, Yeon J, Liu W, Zhang F, Shi FD, Wu X, Thiagarajan P, Li M, Zhang J, Dong JF. Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice. Blood. 2018 Feb 1;131(5):563-572. doi: 10.1182/blood-2017-08-801738. Epub 2017 Nov 21.
Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EA, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100. doi: 10.1186/s13054-016-1265-x.
Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation. 2007;22(5):341-53.
Sun Y, Wang J, Wu X, Xi C, Gai Y, Liu H, Yuan Q, Wang E, Gao L, Hu J, Zhou L. Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases. Br J Neurosurg. 2011 Jun;25(3):363-8. doi: 10.3109/02688697.2011.552650. Epub 2011 Feb 28.
Other Identifiers
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TDSJWKTBIC
Identifier Type: -
Identifier Source: org_study_id
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