Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS
NCT ID: NCT04450355
Last Updated: 2022-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
90 participants
INTERVENTIONAL
2020-07-30
2021-11-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Nefopam group
At the end of induction, the nefopam group will receive intravenous nefopam 20mg mixed with 50ml of normal saline, and at the end of surgery, this group will receive intravenous nefopam 60mg mixed with 50ml of normal saline at a rate of 2ml/hr.
Nefopam 80mg/day
continuous nefopam infusion
Control group
The control group will receive intravenous normal saline 50ml at the end of induction and receive intravenous normal saline 50ml at a rate of 2ml/hr at the end of surgery.
Normal saline
continuous normal saline infusion
Interventions
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Nefopam 80mg/day
continuous nefopam infusion
Normal saline
continuous normal saline infusion
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) physical classification I-II
* Consent to IV-patient controlled analgesia use
* Willingness and ability to sign an informed consent document
Exclusion Criteria
* Allergies to anesthetic or analgesic medications
* Continuous local anesthetics infiltration for postoperative pain control
* Patients who receive mechanical ventilation more than 2 hours after surgery
* Pregnancy/Breast feeder
* Medical or psychological disease that can affect the treatment response
19 Years
70 Years
ALL
No
Sponsors
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Pharmbio Korea
UNKNOWN
Seoul National University Hospital
OTHER
Responsible Party
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Hojin Lee, MD
Clinical assistant professor
Locations
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Seoul National University Hospital
Seoul, , South Korea
Countries
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References
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Tirault M, Derrode N, Clevenot D, Rolland D, Fletcher D, Debaene B. The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth Analg. 2006 Jan;102(1):110-7. doi: 10.1213/01.ANE.0000181103.07170.15.
Du Manoir B, Aubrun F, Langlois M, Le Guern ME, Alquier C, Chauvin M, Fletcher D. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. Br J Anaesth. 2003 Dec;91(6):836-41. doi: 10.1093/bja/aeg264.
Other Identifiers
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2001-036-1092
Identifier Type: -
Identifier Source: org_study_id
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