Hyperlactatemia During and After Tumorcraniotomy

NCT ID: NCT04410315

Last Updated: 2022-08-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-28

Study Completion Date

2022-02-18

Brief Summary

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This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy. The risk factors that induce lactat accumulation will also be explored.

Detailed Description

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Hyperlactatemia is a frequent occurrence in brain tumor surgery. The existing studies, however, are all retrospective, reporting varying effects on clinical outcome. One study reported new neurological deficitis, some found an association with extended hospital stay, while others found no association with outcome. It is therefore important to conduct a prospective study of hyperlactatemia in this patientgroup.

Participants in this study will follow the standard treatment protocol for tumorcraniotomy, aside from 2-3 additional, perioperative blodgas analyses and 2 standardized measurements of neurological disability.

Conditions

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Hyperlactatemia Brain Tumor Surgery Anesthesia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Tumorcraniotomy patients

Serum-lactate < 2,2 mmol/L

Intervention Type OTHER

Bloodgas analysis every hour from start surgery until recovery ward discharge

Serum-lactate >/= 2,2 mmol/L

Intervention Type OTHER

Bloodgas analysis every hour from start surgery until recovery ward discharge

Interventions

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Serum-lactate < 2,2 mmol/L

Bloodgas analysis every hour from start surgery until recovery ward discharge

Intervention Type OTHER

Serum-lactate >/= 2,2 mmol/L

Bloodgas analysis every hour from start surgery until recovery ward discharge

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \>/= 18 years
* Must undergo elective tumor craniotomy
* Understand oral and written Danish

Exclusion Criteria

* Adults with incapacity
* Stereotactic biopsy
* Lack of informed and signed consent to participate in study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Alexandra Vassilieva

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Neuroanesthesiology, Rigshospitalet

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Prosp.Laktat.Tumorkraniotomi

Identifier Type: -

Identifier Source: org_study_id

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