Cerebral Energy State in Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2015-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by microdialysis (MD) of the cerebral venous outflow reflects a derangement of global cerebral energy state during cardiopulmonary bypass.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Surgical Stress Measured by Microdialysis

NCT01495143

Trauma

COMPLETED NA

Cerebral Oxymetry at Elective Coronary and Valve Surgery.

NCT01940874

Coronary Artery Disease. Aortic Valve Stenosis. Aortic Valve Regurgitation.

COMPLETED

Assessing Cerebral Blood Flow Autoregulation During Surgery in the Head-up Position

NCT01225185

Shouldersurgery

COMPLETED

Parameters of Cerebral Perfusion

NCT02806492

Cerebral Perfusion Cerebral Oxygenation Cardiopulmonary Bypass

COMPLETED NA

The Effect on Cerebral Oxygenation of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit in Cardiac Surgery Patients

NCT02108093

Postoperative Cognitive Dysfunction

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients undergoing primary, elective coronary artery bypass grafting were blindly randomized to usual range MAP (40 to 60 mmHg; n = 5) or intervention group MAP (60 to 80 mmHg; n = 5) during CPB. MD catheters were positioned in a retrograde direction in the internal jugular vein and a reference catheter was inserted into the brachial artery. The relations between LP ratio, MAP, data obtained from bi-frontal NIRS and neurological outcome measures were assessed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative; Dysfunction Following Cardiac Surgery

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Low mean arterial perfusion pressure

5 patients undergoing primary, elective coronary artery bypass grafting were randomized to usual range MAP (40 to 60 mmHg) during CPB. Microdialysis catheters were positioned in a retrograde direction in the internal jugular vein.

Group Type EXPERIMENTAL

Microdialysis

Intervention Type PROCEDURE

Extracerebral MD catheters were positioned in a retrograde direction in the internal jugular vein.

High mean arterial perfusion pressure

5 patients undergoing primary, elective coronary artery bypass grafting were blindly randomized to intervention group MAP (60 to 80 mmHg) during CPB. Microdialysis catheters were positioned in a retrograde direction in the internal jugular vein.

Group Type EXPERIMENTAL

Microdialysis

Intervention Type PROCEDURE

Extracerebral MD catheters were positioned in a retrograde direction in the internal jugular vein.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Microdialysis

Extracerebral MD catheters were positioned in a retrograde direction in the internal jugular vein.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

MMSE NIRS

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Elective CABG on CPB

Exclusion Criteria

* Acute patients or reoperations
* Patients with epidural catheter
* Previous stroke
* Stenotic carotids
* Ejection fraction (EF) \< 50 %
* Estimated per operative risk \> 5%

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No