Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

78 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-14

Study Completion Date

2020-04-03

Brief Summary

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Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations. This mechanism is termed cerebrovascular autoregulation and preserves adequate cerebral perfusion in a range between 50 and 150 mmHg of cerebral perfusion pressure. Upper and lower autoregulatory limits may vary individually. Beyond the autoregulatory range the protective autoregulatory response is lost, facilitating cerebral ischemia or hyperemia.

The cerebrovascular response may be altered during general anesthesia, through direct effects of anesthetic agents on the vascular tone, changes of arterial partial pressure of carbon dioxide or the administration of vasoactive substances. The association of perioperative impairment of cerebral autoregulation and postoperative cognitive function has been discussed controversially.

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Detailed Description

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* continuous monitoring of cerebrovascular autoregulation using the correlation method
* based on near-infrared spectroscopy and invasive blood pressure measurement an index (COx) will be calculated
* autoregulation monitoring from anesthesia induction until emergence from anesthesia
* assessment of preoperative cognitive function during preanesthesia evaluation or on the day before surgery
* assessment of postoperative cognitive function between day 3 and 14 following surgery
* evaluation of subjective cognitive complaints or attention deficits 3 months after surgery

Conditions

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Cognitive Function Abnormal Anesthesia Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* elective major non-cardiac/non-vascular surgery
* anticipated surgical duration \>120 minutes
* age \>= 60 years
* indication for invasive blood pressure measurement
* native German speaker