Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
368 participants
INTERVENTIONAL
2018-03-01
2020-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Study group
The intraoperative blood pressure target for all patients in the study group is the mean arterial pressure (+ 10mmHg maximum) derived from the prior 24-hour blood pressure measurement.
To achieve the blood pressure target, fluid or vasoactive substances will be used.
24 hour blood pressure measurement, fluids, vasopressors
Targeting individual blood blood pressure values during surgical procedures
Control group
Study patients of the control group are treated according to the standard operating procedures (SOP) of the Department of Anaesthesiology, University Medical Centre Hamburg Eppendorf.
Standard of Care
Treatment according to Standard of care at the Department of Anaesthesiology, University Medical Centre Hamburg Eppendorf
Interventions
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24 hour blood pressure measurement, fluids, vasopressors
Targeting individual blood blood pressure values during surgical procedures
Standard of Care
Treatment according to Standard of care at the Department of Anaesthesiology, University Medical Centre Hamburg Eppendorf
Eligibility Criteria
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Inclusion Criteria
* ASA II-IV (Classification of the American Society of Anesthesiologists for the assessment of the perioperative risk depending on the underlying diseases)
* duration of intervention in general anesthesia at least 90 minutes
* Impossibility of 24-h blood pressure measurement
Exclusion Criteria
* Emergency procedures
* Surgery requiring controlled hypotension (e.g., aneurysm)
* Cerebrovascular events in the past medical history
* Patients of cardiac surgery, vascular surgery, neurosurgery, and transplantation surgery
* Pre-existing dementia (anamnesis)
* kidney transplant
* dialysis-dependent renal insufficiency (KDIGO criteria)
* no patient consent
50 Years
110 Years
ALL
No
Sponsors
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Universitätsklinikum Hamburg-Eppendorf
OTHER
Responsible Party
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Locations
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Klinik und Poliklinik für Anästhesiologie, Zentrum für Anästhesiologie und Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf
Hamburg, , Germany
Countries
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References
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Nicklas JY, Bergholz A, Dake F, Pham HHD, Rabe MC, Schlichting H, Skrovanek S, Flick M, Kouz K, Fischer M, Olotu C, Izbicki JR, Mann O, Fisch M, Schmalfeldt B, Frosch KH, Renne T, Krause L, Zollner C, Saugel B. Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial. BJA Open. 2024 Jul 1;11:100294. doi: 10.1016/j.bjao.2024.100294. eCollection 2024 Sep.
Other Identifiers
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IMPROVE-1.0
Identifier Type: -
Identifier Source: org_study_id
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