Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-30

Study Completion Date

2018-08-02

Brief Summary

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In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.

This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.

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Detailed Description

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Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.

Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.

The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.

Conditions

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Brain Tumor Anesthesia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Lactate and Ki 67 levels

Neurosurgical patients between June 2017 and February 2018 for tumoral and non-tumoral craniectomy with lactate levels at the beginning of surgery and Ki-67 index in biopsies.

Data correlation

Intervention Type OTHER

Correlation between lactate levels and Ki-67 index

Interventions

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Data correlation

Correlation between lactate levels and Ki-67 index

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Neurosurgical craniectomy cases
* June 2017 - February 2018
* Valid lactate information after anesthesia induction
* Ki-67 label index informed in biopsies
* Tumor type information confirmed in biopsies