Awake Proning in COVID-19 Patients With Hypoxemic Respiratory Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

29 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-16

Study Completion Date

2022-03-06

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to retrospectively review clinical data to determine whether awake proning improves oxygenation in spontaneously breathing patients with COVID-19 severe hypoxemic respiratory failure.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

NCT05866289

Survival, Prosthesis Oxygen Deficiency

COMPLETED

Awake Prone Position for Early Hypoxemia in COVID-19

NCT04344587

COVID-19

COMPLETED NA

Timed Awake Prone and Repositioning for Patients With Covid-19-induced Hypoxic Respiratory Failure.

NCT05689216

Corona Virus Infection Hypoxic Respiratory Failure

UNKNOWN NA

Awake-Prone Positioning Strategy for Hypoxic Patients With COVID-19

NCT04547283

Covid19 Respiratory Failure

COMPLETED NA

Awake Prone Position in Hypoxemic Patients With Coronavirus Disease 19 COVID-19 (COVI-PRONE)

NCT04350723

Corona Virus Infection Covid19 COVID-19

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Critically ill patients with coronavirus disease 2019 (COVID-19) severely strained intensive care resources in New York in April 2020. The prone position improves oxygenation in intubated patients with acute respiratory distress syndrome. The investigators wanted to study whether the prone position is associated with improved oxygenation and decreased risk for intubation in spontaneously breathing patients with severe COVID-19 hypoxemic respiratory failure. Awake prone positioning was implemented based on the health care provider decision.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Oxygen Deficiency Coronavirus Infection

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Awake Proning

COVID-19 patients with hypoxemic respiratory failure with awake prone positioning, as tolerated, up to 24 hours daily.

Awake proning

Intervention Type OTHER

Prone positioning of awake, as tolerated, for up to 24 hours daily.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Awake proning

Prone positioning of awake, as tolerated, for up to 24 hours daily.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Consecutive patients admitted to the Columbia University step-down unit from April 6, 2020.
* Laboratory confirmed COVID-19 infection with severe hypoxemic respiratory failure defined as respiratory rate ≥30 breaths/min and oxyhemoglobin saturation (SpO2) ≤93% while receiving supplemental oxygen 6 L/min via nasal cannula and 15 L/min via non-rebreather facemask.