Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
160 participants
INTERVENTIONAL
2021-07-08
2026-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Placebo
Smoked Cannabis (\~0% THC)
Placebo Cannabis
Placebo smoked cannabis (no THC)
Low strength cannabis
Smoked Cannabis (\~4% THC)
Active Cannabis
Smoked cannabis with THC
Higher strength cannabis
Smoked Cannabis (\~10% THC)
Active Cannabis
Smoked cannabis with THC
Interventions
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Active Cannabis
Smoked cannabis with THC
Placebo Cannabis
Placebo smoked cannabis (no THC)
Eligibility Criteria
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Inclusion Criteria
* Report use of cannabis an average of 1-7 days per week
* Not currently seeking treatment for their cannabis use
* Urine test positive for recent cannabis use for heavy users
* No reported adverse effects with cannabis smoking in light users
* Have a Body Mass Index from 18.5 - 34kg/m2.
* Able to perform all study procedures
* FEMALES: Currently practicing a non-hormonal effective form of birth control
* FEMALES: Must be regularly cycling
Exclusion Criteria
* Report using other illicit drugs in the prior 4 weeks
* History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
* Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
* Current pain
* Insensitivity to the cold water stimulus of the Cold Pressor Test
* FEMALES: using a hormonal contraceptive
21 Years
55 Years
ALL
Yes
Sponsors
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National Institute on Drug Abuse (NIDA)
NIH
University of California, Los Angeles
OTHER
Responsible Party
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Ziva D. Cooper, PhD
Associate Professor
Principal Investigators
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Ziva Cooper, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California, Los Angeles
Locations
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University of California, Los Angeles
Los Angeles, California, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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19-000876
Identifier Type: -
Identifier Source: org_study_id
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