Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1
NCT ID: NCT05868213
Last Updated: 2024-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
96 participants
OBSERVATIONAL
2022-08-17
2024-12-15
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This study tests the effects of commercially available cannabis flower strains on recognition memory performance and ERPs that are related to different underlying memory processes in healthy, regular cannabis users. An episodic memory task is used to assess recognition memory, which asks participants to discriminate between previously studied and non-studied items using words as stimuli. Participants complete the same memory task while intoxicated one day and not intoxicated another day. A THC-dominant, a CBD-dominant, and a strain containing both THC and CBD are included in the study. Participants self-administer one of the three cannabis strains prior to memory encoding and retrieval.
Blood is collected to determine THC and CBD exposure, as well as to explore how genetic variation in genes related to cannabinoid metabolism, cannabis-related behavior, and neurocognitive function associate with memory function before and after cannabis use. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Cannabis (smoked flower)
Self-Directed Use (ad-libitum)
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Must be right-handed (Laterality Quotient \> 60 on Edinburgh Handedness Inventory - Short Form).
* Must use cannabis at least 4 days during the month.
* Must be a cannabis user for at least a year.
* Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days.
* Must not test positive on a urine toxicology test for drugs of abuse.
* Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days.
* Must not be a regular tobacco user (≤4 days per week; cigarette, E-cigs, or smokeless).
* Must not have used caffeine or tobacco (cigarette, E-cigs, or smokeless) for 4 hours prior to appointments.
* Must have a breath alcohol level of 0 to sign consent form.
* Must not be actively seeking or in treatment for any substance use disorder.
* Female subjects must not be or trying to become pregnant.
* Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders.
* Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.
21 Years
40 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute on Drug Abuse (NIDA)
NIH
University of Colorado, Boulder
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
L. Cinnamon Bidwell
Assistant Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Tim Curran, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Boulder
L. Cinnamon Bidwell, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Boulder
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Center for Innovation and Creativity
Boulder, Colorado, United States
Countries
Review the countries where the study has at least one active or historical site.
Related Links
Access external resources that provide additional context or updates about the study.
More information
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
20-0309: Experiment 1
Identifier Type: -
Identifier Source: org_study_id