Low Creatinine Level and Respiratory Failure

NCT ID: NCT04368325

Last Updated: 2020-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

107 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-17

Study Completion Date

2017-06-16

Brief Summary

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Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

Detailed Description

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The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.

Conditions

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Intensive Care Unit Respiratory Insufficiency Muscle Weakness

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Study group

Total of 46 patients with low serum creatinine levels whose values were obtained from the central laboratory with inclusion criteria (\< 40mmol/L)

Serum creatinine levels

Intervention Type DIAGNOSTIC_TEST

Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups

Control group

A total of 61 consecutive patients were obtained who were treated in ICU CHC Osijek, according to the date of admission.

Serum creatinine levels

Intervention Type DIAGNOSTIC_TEST

Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups

Interventions

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Serum creatinine levels

Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Exclusion Criteria

* Patients who were younger than 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Josip Juraj Strossmayer University of Osijek

OTHER

Sponsor Role collaborator

Osijek University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Slavica Kvolik, MD; PhD.

Role: STUDY_CHAIR

Osijek University Hospital

Locations

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University hospital centre Osijek

Osijek, , Croatia

Site Status

Countries

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Croatia

References

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Vo P, Kharasch VS. Respiratory failure. Pediatr Rev. 2014 Nov;35(11):476-84; quiz 485-6. doi: 10.1542/pir.35-11-476.

Reference Type BACKGROUND
PMID: 25361907 (View on PubMed)

Briones Claudett KH. Noninvasive ventilation in the event of acute respiratory failure in patients with idiopathic pulmonary fibrosis: waiting for? J Crit Care. 2014 Dec;29(6):1128. doi: 10.1016/j.jcrc.2014.07.016. Epub 2014 Jul 22. No abstract available.

Reference Type BACKGROUND
PMID: 25201432 (View on PubMed)

Schwabbauer N, Berg B, Blumenstock G, Haap M, Hetzel J, Riessen R. Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). BMC Anesthesiol. 2014 Aug 7;14:66. doi: 10.1186/1471-2253-14-66. eCollection 2014.

Reference Type BACKGROUND
PMID: 25110463 (View on PubMed)

Zielinski J, MacNee W, Wedzicha J, Ambrosino N, Braghiroli A, Dolensky J, Howard P, Gorzelak K, Lahdensuo A, Strom K, Tobiasz M, Weitzenblum E. Causes of death in patients with COPD and chronic respiratory failure. Monaldi Arch Chest Dis. 1997 Feb;52(1):43-7.

Reference Type BACKGROUND
PMID: 9151520 (View on PubMed)

Pettenuzzo T, Fan E. 2016 Year in Review: Mechanical Ventilation. Respir Care. 2017 May;62(5):629-635. doi: 10.4187/respcare.05545.

Reference Type BACKGROUND
PMID: 28442589 (View on PubMed)

Sahetya S, Allgood S, Gay PC, Lechtzin N. Long-Term Mechanical Ventilation. Clin Chest Med. 2016 Dec;37(4):753-763. doi: 10.1016/j.ccm.2016.07.014. Epub 2016 Oct 14.

Reference Type BACKGROUND
PMID: 27842754 (View on PubMed)

De Jonghe B, Bastuji-Garin S, Durand MC, Malissin I, Rodrigues P, Cerf C, Outin H, Sharshar T; Groupe de Reflexion et d'Etude des Neuromyopathies en Reanimation. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med. 2007 Sep;35(9):2007-15. doi: 10.1097/01.ccm.0000281450.01881.d8.

Reference Type BACKGROUND
PMID: 17855814 (View on PubMed)

Datta D, Foley R, Wu R, Grady J, Scalise P. Can Creatinine Height Index Predict Weaning and Survival Outcomes in Patients on Prolonged Mechanical Ventilation After Critical Illness? J Intensive Care Med. 2018 Feb;33(2):104-110. doi: 10.1177/0885066616648133. Epub 2016 May 13.

Reference Type BACKGROUND
PMID: 27179057 (View on PubMed)

Lai YC, Ruan SY, Huang CT, Kuo PH, Yu CJ. Hemoglobin levels and weaning outcome of mechanical ventilation in difficult-to-wean patients: a retrospective cohort study. PLoS One. 2013 Aug 28;8(8):e73743. doi: 10.1371/journal.pone.0073743. eCollection 2013.

Reference Type BACKGROUND
PMID: 24015310 (View on PubMed)

Lee JJ, Waak K, Grosse-Sundrup M, Xue F, Lee J, Chipman D, Ryan C, Bittner EA, Schmidt U, Eikermann M. Global muscle strength but not grip strength predicts mortality and length of stay in a general population in a surgical intensive care unit. Phys Ther. 2012 Dec;92(12):1546-55. doi: 10.2522/ptj.20110403. Epub 2012 Sep 13.

Reference Type BACKGROUND
PMID: 22976446 (View on PubMed)

Ellis CS. Improving Nutrition in Mechanically Ventilated Patients. J Neurosci Nurs. 2015 Oct;47(5):263-70; quiz E1. doi: 10.1097/JNN.0000000000000161.

Reference Type BACKGROUND
PMID: 26348431 (View on PubMed)

Coudroy R, Jamet A, Petua P, Robert R, Frat JP, Thille AW. High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study. Ann Intensive Care. 2016 Dec;6(1):45. doi: 10.1186/s13613-016-0151-7. Epub 2016 May 20.

Reference Type BACKGROUND
PMID: 27207177 (View on PubMed)

Weiler N, Waldmann J, Bartsch DK, Rolfes C, Fendrich V. Outcome in patients with long-term treatment in a surgical intensive care unit. Langenbecks Arch Surg. 2012 Aug;397(6):995-9. doi: 10.1007/s00423-012-0966-0. Epub 2012 Jun 15.

Reference Type BACKGROUND
PMID: 22699745 (View on PubMed)

van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nurnberg P, Bonten MJ, Cremer OL, van der Poll T; MARS Consortium. Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. JAMA. 2016 Apr 12;315(14):1469-79. doi: 10.1001/jama.2016.2691.

Reference Type BACKGROUND
PMID: 26975785 (View on PubMed)

Other Identifiers

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OsijekUH-7

Identifier Type: -

Identifier Source: org_study_id

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