Anemia and Duration of Mechanical Ventilation

NCT ID: NCT05382065

Last Updated: 2022-08-22

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 250 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-07-08
• Study Completion Date: 2023-12-31

Brief Summary

In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. We aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support >96 hr.

Detailed Description

Anemia is one of the most common conditions encountered critically ill patients. Various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. Anemia can affect cardiopulmonary function as depletion in oxygen content in body. In mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. Some research suggested that hemoglobin level <8.5 g/dl was a potential risk factor for adverse outcome in critically ill patients required mechanical ventilation >96 hr. However, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. To the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. We hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. We, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support >96 hours.

Conditions

Anemia; Mechanical Ventilation; Critically Ill; Intensive Care Unit; Morality; Organ Dysfunction Syndrome

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Patients whose age of equal or more than 18 years old
• Patients admitted to the surgical intensive care unit during the study period
• Patients required ventilatory support with invasive mechanical ventilation for more than 96 hours

Exclusion Criteria

• Patients whose data regarding time of beginning or ending of ventilatory support missed
• Patients who are previously included in this study and are re-admitted

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mahidol University

OTHER

Sponsor Role: lead

Responsible Party

Annop Piriyapatsom, MD

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Annop Piriyapatsom, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Locations

Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, Thailand

Site Status: RECRUITING

Countries

Thailand

Central Contacts

Annop Piriyapatsom, MD

Role: CONTACT

annop.pir@mahidol.ac.th

+6624197990

Facility Contacts

Annop Piriyapatsom, MD

Role: primary

annop.pir@mahidol.ac.th

+6624197990

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Reference Type: BACKGROUND

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Other Identifiers

255/2565(IRB3)

Identifier Type: -

Identifier Source: org_study_id