Post Exercise Substrate Oxidation, Appetite and Energy Intakes in Overweight/Obese Postmenopausal Women (EScAPE)

NCT ID: NCT04364061

Last Updated: 2020-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-01

Study Completion Date

2020-04-01

Brief Summary

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High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

Detailed Description

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The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity.

Using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals:

i) Moderate Intensity Continuous Exercise (MICE) which consisted of 35 min cycling at 60-65% theorical Peak Heart Rate (thPHR) ii) High Intensity Interval Exercise 1 (HIIE 1) 60 cycles of speeding up for 8 s at 80-90%thPHR followed by pedaling slowly for 12 s (20min) iii) High Intensity Interval Exercise 2 (HIIE 2) which consisted of repeated 10 x 1min at 80-90% thPHR followed by pedaling slowly for 1min.

Substrate oxidation (CHO and FAT) were measured at rest and 2h- post exercise. Enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

Conditions

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Overweight Postmenopausal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Data collected on the volunteers will be made anonymous

Study Groups

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Women with overweight or obesity

Group Type EXPERIMENTAL

Moderate Intensity Continuous Exercise

Intervention Type OTHER

Participant completed a moderate intensity continuous cycling exercise (MICE) during 35 min at 60-65% thPHRmax

High-Intensity Interval Exercise (1)

Intervention Type OTHER

Participant completed a high-intensity interval cycling exercise (HIIE 1) during 20min with 60 cycles of speeding up for 8s and pedaling slowly for 12s at 80-90% thPHRmax

High-Intensity Interval Exercise (2)

Intervention Type OTHER

Participant completed a high-intensity interval cycling exercise (HIIE 2) during 20min with 10 x 1-min bouts at 80-90% thPHRmax, separated by 1-min recovery bouts

Interventions

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Moderate Intensity Continuous Exercise

Participant completed a moderate intensity continuous cycling exercise (MICE) during 35 min at 60-65% thPHRmax

Intervention Type OTHER

High-Intensity Interval Exercise (1)

Participant completed a high-intensity interval cycling exercise (HIIE 1) during 20min with 60 cycles of speeding up for 8s and pedaling slowly for 12s at 80-90% thPHRmax

Intervention Type OTHER

High-Intensity Interval Exercise (2)

Participant completed a high-intensity interval cycling exercise (HIIE 2) during 20min with 10 x 1-min bouts at 80-90% thPHRmax, separated by 1-min recovery bouts

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* postmenopausal women (spontaneous amenorrhea for at least 12 months)
* with overweight or obesity (BMI \> 25 kg/m2 and ≤ 40 kg/m2)

Exclusion Criteria

* medical contraindications to intense physical activity,
* painful joints,
* taking hormone replacement therapy,
* taking B-blockers.
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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CREPS Auvergne Rhône-Alpes / Vichy

UNKNOWN

Sponsor Role collaborator

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Claire MOREL, Dr

Role: PRINCIPAL_INVESTIGATOR

CREPS Auvergne Rhône-Alpes / Vichy

Locations

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CREPS Auvergne Rhône-Alpes / Vichy

Bellerive-sur-Allier, Allier, France

Site Status

Countries

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France

Other Identifiers

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IRB00012476-2020-24-03-50

Identifier Type: -

Identifier Source: org_study_id

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