Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
178 participants
OBSERVATIONAL
2020-06-09
2023-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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no shunt, no lung injury
ventilated newborns / infants / children with healthy lungs and without or corrected congenital heart disease and no intra-/extra-cardiac shunt
capnography monitoring
routinely used capnography monitoring
arterial blood gas
Routinely taken arterial blood gas values
mild lung injury
ventilated newborns / infants / children with mild lung injury (OI between 4 and 8)
capnography monitoring
routinely used capnography monitoring
arterial blood gas
Routinely taken arterial blood gas values
moderate-severe lung injury
ventilated newborns / infants / children with moderate or severe lung injury (OI above 8)
capnography monitoring
routinely used capnography monitoring
arterial blood gas
Routinely taken arterial blood gas values
shunt lesion
ventilated newborns / infants / children with cyanotic heart diseases and therefore existing intra-cardiac or extra- cardiac right-left shunt lesions
capnography monitoring
routinely used capnography monitoring
arterial blood gas
Routinely taken arterial blood gas values
Interventions
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capnography monitoring
routinely used capnography monitoring
arterial blood gas
Routinely taken arterial blood gas values
Eligibility Criteria
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Inclusion Criteria
* Newborns with a birthweight of at least 2.0 kg
* Newborns with an age of at least 1 hour (age \> 60 minutes)
* Children up to the last day of the 13th year of living
* Ability of care taker or patient to understand verbal and written instructions and the general consent or informed consent in German or English
* Obtained written general or informed consent as documented by signature
* Available arterial line, i.e. a specific catheter inserted in an artery
Exclusion Criteria
* Care taker not available
* Newborns with a birthweight below 2.0 kg
* Newborns younger than 1 hour (age \<60 minutes)
* Children with an age of 14 years onwards
* Missing arterial line
* Patients dependent on any other kind of respiratory support that is not compatible with the PcCO2-sensor or where a high leakage in the respiratory circuit makes PcCO2 measurements impossible (nasal mask ventilation, low-flow-/high-flow-ventilation, rebreathing mask, high- frequency-oscillation)
* Patients where the investigators act on the assumption that mechanical ventilation will be discontinued and/or the arterial line will be removed within 6 hours or where only one pair of values (arterial and endtidal CO2) can be compared
* Patients with a cyanotic shunt lesion with a weight of 15 kg or above
1 Hour
13 Years
ALL
Yes
Sponsors
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Vincenzo Cannizzaro
OTHER
Responsible Party
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Vincenzo Cannizzaro
Senior consultant and head of research
Locations
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University Children's Hospital
Zurich, , Switzerland
Countries
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Other Identifiers
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KISPI-CAPNO
Identifier Type: -
Identifier Source: org_study_id
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