Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
NCT ID: NCT06051292
Last Updated: 2025-03-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
27 participants
INTERVENTIONAL
2023-09-18
2025-12-30
Brief Summary
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However, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters.
To address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Fast decremental
fast decremental catheter volume titration will be applied
Fast method
Fast decremental catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Conventional
conventional catheter volume titration will be applied
Conventional method
Conventional catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Interventions
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Fast method
Fast decremental catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Conventional method
Conventional catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Eligibility Criteria
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Inclusion Criteria
* Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours
* Informed consent was signed by next of kin
* Requiring esophageal catheter application
Exclusion Criteria
* Patient included in another interventional study in the last 30 days
* Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies
* Patient included in another interventional research study under consent
* Patient already enrolled in the present study in a previous episode of acute respiratory failure
1 Month
18 Years
ALL
No
Sponsors
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Dr. Behcet Uz Children's Hospital
OTHER
Responsible Party
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Hasan ağın
Professor
Principal Investigators
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Hasan Agin, Professor
Role: STUDY_DIRECTOR
Behcet Uz Children's Hospital
Locations
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Aydin Obstetric and pediatrics Hospital
Aydin, , Turkey (Türkiye)
Erzurum Regional Research and Training Hospital
Erzurum, , Turkey (Türkiye)
Cam Sakura Research and Training Hospital
Istanbul, , Turkey (Türkiye)
The Health Sciences University Izmir Behçet Uz Child Health and Diseases Research and Training Hospital
Izmir, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Mojoli F, Chiumello D, Pozzi M, Algieri I, Bianzina S, Luoni S, Volta CA, Braschi A, Brochard L. Esophageal pressure measurements under different conditions of intrathoracic pressure. An in vitro study of second generation balloon catheters. Minerva Anestesiol. 2015 Aug;81(8):855-64. Epub 2015 Jan 30.
Hotz JC, Sodetani CT, Van Steenbergen J, Khemani RG, Deakers TW, Newth CJ. Measurements Obtained From Esophageal Balloon Catheters Are Affected by the Esophageal Balloon Filling Volume in Children With ARDS. Respir Care. 2018 Feb;63(2):177-186. doi: 10.4187/respcare.05685. Epub 2017 Oct 31.
Mojoli F, Iotti GA, Torriglia F, Pozzi M, Volta CA, Bianzina S, Braschi A, Brochard L. In vivo calibration of esophageal pressure in the mechanically ventilated patient makes measurements reliable. Crit Care. 2016 Apr 11;20:98. doi: 10.1186/s13054-016-1278-5.
Other Identifiers
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02020395
Identifier Type: -
Identifier Source: org_study_id
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