Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

NCT ID: NCT06203353

Last Updated: 2024-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-01

Study Completion Date

2024-12-30

Brief Summary

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Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support).

Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Detailed Description

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This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale \> 13 Requiring no vasopressor support

conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test.

Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Conditions

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Mechanical Ventilation Weaning

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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weaning success

Patients extubated with no need to non invasive ventilatry support during 48 hours

diaphragm ultrasound monitoring

Intervention Type DIAGNOSTIC_TEST

Ultrasound measure the diaphragm excursion, thickening fraction and maximal contraction and relaxation velocities

weaning failure

patients requiring reintubation or non invasive ventilation within 48 hours after extubation

diaphragm ultrasound monitoring

Intervention Type DIAGNOSTIC_TEST

Ultrasound measure the diaphragm excursion, thickening fraction and maximal contraction and relaxation velocities

Interventions

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diaphragm ultrasound monitoring

Ultrasound measure the diaphragm excursion, thickening fraction and maximal contraction and relaxation velocities

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Invasive mechanical ventilation for at least 48 hours

Exclusion Criteria

* reintubation for extra respiratory failure (neurologic or hemodynamic)
* Patients with chronic repiratory failure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mongi Slim Hospital

OTHER

Sponsor Role lead

Responsible Party

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Mhamed Sami Mebazaa

Professor head of anesthesiology and ICU department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Mongi Slim hospital

Tunis, , Tunisia

Site Status RECRUITING

Countries

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Tunisia

Central Contacts

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Mhamed Mebazaa, professor

Role: CONTACT

22252589 ext. 00216

Asma Ben Souissi, Asso Prof

Role: CONTACT

98336883 ext. 00216

Facility Contacts

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Mhamed sami Mebazaa, Pr

Role: primary

22252589 ext. 00216

Asma Ben Souissi, Asso Pr

Role: backup

98336883 ext. 00216

Other Identifiers

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Diaphram Tissue Doppler

Identifier Type: -

Identifier Source: org_study_id

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