Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
10 participants
INTERVENTIONAL
2020-01-08
2024-12-30
Brief Summary
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The study will be an acute single blind, randomised controlled, crossover intervention study in healthy, young volunteers. Participants receive either the test watermelon drink or control drink (water). Blood samples and vascular measures (by a single-cuff based method) will be measured at baseline. Vascular measures will be repeated at 15-minute intervals between 0-2 hours and a second blood sample will be drawn at 1.5 hours to coincide with the estimated peak plasma L-citrulline. Citrulline, arginine and nitric oxide metabolites will be measured in the blood samples.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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Active
Watermelon juice
Watermelon Juice
500 mL watermelon juice (What a Melon), containing \~1 g of L-citrulline.
Control
Low nitrate water.
Water
500 mL low nitrate water
Interventions
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Watermelon Juice
500 mL watermelon juice (What a Melon), containing \~1 g of L-citrulline.
Water
500 mL low nitrate water
Eligibility Criteria
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Inclusion Criteria
* 18-30 years
Exclusion Criteria
* Willing to comply with the study protocol
* Able to give informed consent.
* Medical history of myocardial infarction
* Medical history of angina
* Medical history of thrombosis
* Medical history of stroke
* Medical history of cancer
* Medical history of high cholesterol
* Medical history of liver diseases
* Medical history of renal diseases
* Medical history of respiratory diseases
* Medical history of bowel diseases
* Medical history of diabetes
* Medical history of other endocrine disorders
* BMI \<18.5 kg/m2 or \>25 kg/m2
* Blood pressure \<90/60 or \> 140/90 mmHg
* Current use of antihypertensive medication
* Pregnant or lactating
* Alcohol intake \> 14 units/week
* Cigarette smoker (or quit within the last 6 months)
* Vigorous exercise \> 3 times/ week
18 Years
30 Years
ALL
Yes
Sponsors
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University of Reading
OTHER
Responsible Party
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Charlotte E Mills
Lecturer
Locations
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University of Reading
Reading, UK, United Kingdom
Countries
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Other Identifiers
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34/19
Identifier Type: -
Identifier Source: org_study_id
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