Educational Program Plus Physiotherapy After Prostatectomy

NCT ID: NCT04284020

Last Updated: 2020-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-01

Study Completion Date

2022-12-31

Brief Summary

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Objective: to find out the effectiveness of therapeutic education program plus pelvic-perineal physical therapy in radical robotic prostatectomy men in terms of quality of life (QoL), urinary incontinence (UI), erectile dysfunction (ED) and muscle strength.

Design: Randomized, controlled and single blinded clinical trial. Participants will be randomly assigned in two groups. Experimental group: training pelvic-perineal physical therapy plus lifestyle education. Control group: training in pelvic-perineal physical therapy only. In the 2 groups several physical therapy measurements will be undertaken: 1st before physical therapy treatment, 2nd, 3 th and 4th after 3, 6 and 12 months after initial measurement.

Study subjects: Post radical robotic prostatectomy men, which have not been already treated with adjuvant treatment and pelvic-perineal physical therapy, and after reading, understanding and freely signing an informed consent form.

Sample size: 84 subjects will be included (42 subjects per group). To have a statistical power of 90% to detect an average difference of 10 points between two groups in the change of quality of life according to the questionnaire validated in Spanish SF-12, assuming a standard deviation of the change of 20 points based on the study from Hou et al, establishing an alpha risk of 0.05, in a bilateral contrast and assuming a 10% of drops outs.

Data analysis: Separate analyzes of each variable collected in the two groups will be carried out. For continuous variables, means, medians, standard deviations and quartiles will be calculated, depending on the assumption or not, respectively, of the assumption of their normality previously determined with the Shapiro Wilk test (S-W). Qualitative variables will be described with absolute and relative percentage frequencies. Effectiveness will be evaluated by comparing between the two groups of the change in outcome variables between measurements.

Detailed Description

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Conditions

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Prostate Cancer Side Effects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

two groups: 1 experimental and 1 control group
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Educational program & pelvic floor muscle training

The educational strategy will consist of explaining a healthy lifestyle guide with videos, mobile apps and activities about the anatomy of the pelvic floor and the physiology of the pelvic organs. It will be recommended to avoid risk factors, such as gaining weight, high impact sports, constipation, smoking, or drinking too much caffeine and alcohol. They will also instruct in toilet habits.

The pelvic floor muscle training (PFMT) protocol will be applied. Participants will perform exercises with anal biofeedback, perineal and erectile dysfunction electrotherapy protocol and surface electromyography. They will perform PFMT in supine position, sitting, standing and walking. The intervention will last 5 weeks, 2 sessions per week. Each session will last 30/40 minutes.

If the patients have overactive bladder symptoms they will perform transcutaneous tibial nerve stimulation (TTNS) protocol. The intervention will last 5 weeks, 2 sessions per week. Each session will last 30 minutes.

Group Type EXPERIMENTAL

Therapeutic educational program

Intervention Type BEHAVIORAL

See arm/group descriptions

PFMT

Intervention Type OTHER

See arm/group descriptions

TTNS

Intervention Type OTHER

See arm/group descriptions

PFMT group

They will receive a basic behavioral educational strategy in the first session including pelvic anatomy and physiology, recommendations to avoid risk factors and toilet habits.

The PFMT protocol will be applied. Participants will perform PFMT exercises with anal biofeedback, perineal and erectile dysfunction electrotherapy protocol and surface electromyography. They will perform PFMT in supine position, sitting, standing and walking. The intervention will last 5 weeks, 2 sessions per week. Each session will last 30/40 minutes.

If the patients have overactive bladder symptoms they will perform transcutaneous tibial nerve stimulation (TTNS) protocol. The intervention will last 5 weeks, 2 sessions per week. Each session will last 30 minutes.

Group Type ACTIVE_COMPARATOR

PFMT

Intervention Type OTHER

See arm/group descriptions

TTNS

Intervention Type OTHER

See arm/group descriptions

Interventions

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Therapeutic educational program

See arm/group descriptions

Intervention Type BEHAVIORAL

PFMT

See arm/group descriptions

Intervention Type OTHER

TTNS

See arm/group descriptions

Intervention Type OTHER

Other Intervention Names

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Pelvic floor muscle training Transcutaneous tibial nerve stimulation

Eligibility Criteria

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Inclusion Criteria

* Men had undergone radical robotic prostate surgery.
* Men reading, understanding and freely signing an informed consent form.

Exclusion Criteria

* Participants who had received adjuvant therapies (chemotherapy, radiotherapy) before pelvic-perineal physical therapy treatment.
* Men with a history of pelvic organ surgery.
* Men with chronic diseases that affects their quality of life.
* Participants with psychiatric or neurological problems.
* Postoperative men with cognitive limitations to understand information, respond to questionnaires, consent and / or participate in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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University of Alcala

OTHER

Sponsor Role lead

Responsible Party

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Cristina Romojaro Perez

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maria Torres-Lacomba, PhD

Role: STUDY_DIRECTOR

University of Alcalá. FPSM research group. HUPA

Beatriz Navarro-Brázalez, PhD

Role: STUDY_CHAIR

University of Alcalá. FPSM research group. HUPA

Locations

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University of Alcalá. FPSM research group. HUPA

Alcalá de Henares, Madrid, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Cristina Romojaro-Pérez, PhD student

Role: CONTACT

Cristina Romojaro-Pérez, PhD student

Role: CONTACT

915 75 96 51

Facility Contacts

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María Torres-Lacomba, PhD

Role: primary

Cristina Romojaro-Pérez, PhD student

Role: backup

Other Identifiers

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4/2018

Identifier Type: -

Identifier Source: org_study_id

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