Prevalence , Risk Factors and Outcomes of AKI in ICU Patients

NCT ID: NCT04264507

Last Updated: 2021-07-23

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 254 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-01-01
• Study Completion Date: 2021-12-31

Brief Summary

Early recognition of AKI is essential to ensure prompt and appropriate management, and to avoid progression to late stages of the disease (2) AKI requiring renal replacement therapy occurs in 5-6% of ICU patients, with an extremely high in hospital mortality rate of 60%.6 It is estimated that about 2 million people die of AKI every year. Those who survive AKI have a higher risk for later development of CKD(3). Epidemiology of AKI is understudied in developing countries so further studies are needed to estimate the burden of AKI among ICU patients.

Few studies about the epidemiology of AKI in Egypt were done;

Detailed Description

Acute kidney injury is a sudden episode of kidney failure or damage that happens within a few hours or days. According to KDIGO (kidney disease improving global outcomes) criteria: AKI is defined as any of the following: Increase in serum creatinine by 0.3mg/dL or more within 48 hours or. Increase in serum creatinine to 1.5 times baseline or more within the last 7 days or. Urine output less than 0.5 mL/kg/h for 6 hours(1). Kidney Injury (AKI) affects over 13 million people per year globally and results in 1.7 million deaths. Recent hospital studies in the developed world report AKI in 3.2-9.6% of admissions, with overall in-hospital mortality around 20%, and up to 50% in ICU patients.

Early recognition of AKI is essential to ensure prompt and appropriate management, and to avoid progression to late stages of the disease (2) AKI requiring renal replacement therapy occurs in 5-6% of ICU patients, with an extremely high in hospital mortality rate of 60%.6 It is estimated that about 2 million people die of AKI every year. Those who survive AKI have a higher risk for later development of CKD(3). Epidemiology of AKI is understudied in developing countries so further studies are needed to estimate the burden of AKI among ICU patients.

Few studies about the epidemiology of AKI in Egypt were done; Samar Abd ElHafeez e,tal 2017 found in a multicenter study of over 500 consecutive patients admitted to ICUs in Alexandria Teaching Hospitals in Egypt, that about 40% of patients admitted to ICU had AKI at presentation, and a similar proportion of those who were AKI-free on admission developed AKI during their ICU stay (4) .

Up to our knowledge, there are no sufficient data about the epidemiology of AKI in upper Egypt

Conditions

Acute Kidney Injury

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• All patients >18 years admitted to medical ICU in Internal Medicine Department with critical medical conditions who develop AKI during hospital admission or presented with AKI

Exclusion Criteria

• Patients with ESRD on regular dialysis ,Patients with stage 4 or 5 non-dialysis if the condition proven to be progression of the already known diagnosis.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

manal adel ahmed

resident doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Walaa Hosny, Doctor

Role: STUDY_DIRECTOR

Assiut University

Locations

Assiut university Hospital

Asyut, Assuit, Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

manal ahmed, master

Role: CONTACT

manalahmed1993@gmail.com

01156949520

Facility Contacts

Manal Adel, Master

Role: primary

Manalahmed1993@gmail.com

01140122723

References

Summary of Recommendation Statements. Kidney Int Suppl (2011). 2012 Mar;2(1):8-12. doi: 10.1038/kisup.2012.7. No abstract available.

Reference Type: RESULT

PMID: 25018916 (View on PubMed)

Related Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089654/

Summary of Recommendation Statements. Kidney Int Suppl

Other Identifiers

Epidemiology of aki in icu

Identifier Type: -

Identifier Source: org_study_id