Risk Factors And Outcomes Of Hospital Acquired AKI

NCT ID: NCT06051708

Last Updated: 2024-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-01

Study Completion Date

2024-05-15

Brief Summary

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The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.

Detailed Description

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Hospital-acquired AKI (HAAKI) is defined as acute renal insult occurring 48 hours or more after admission to a health care facility and It is estimated to occur in 13-18% of hospitalized patients. The early diagnosis of HAAKI reflects on improvement in morbidity and mortality rates especially in developing countries which goes parallel with the goal The International Society of Nephrology (ISN) to eliminate preventable or treatable deaths from AKI by 2025, the "0 by 25" initiative.

Data concerning the spectrum of acute kidney injury (AKI) in Egypt are generally scarce.

Conditions

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AKI - Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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AKI group

patients who are hospitalized and develop acute kidney injury after 48 hours from admission

standard AKI care bundle

Intervention Type OTHER

AKI care bundle include use of iv fluids, diuretics, antihyperkalemic drugs, sodium bicarbonate, antibiotics in septic patients.

no AKI group

patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge

standard care for hospitalized patients

Intervention Type OTHER

this includes iv fluids, diuretics, antibiotics in septic patients, other measures according to original disease

Interventions

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standard AKI care bundle

AKI care bundle include use of iv fluids, diuretics, antihyperkalemic drugs, sodium bicarbonate, antibiotics in septic patients.

Intervention Type OTHER

standard care for hospitalized patients

this includes iv fluids, diuretics, antibiotics in septic patients, other measures according to original disease

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Fulfilment of definition of acute kidney injury according to KDIGO reference.
2. Age more than 18 years.

Exclusion Criteria

1. Mentally or physically unfit patients.
2. Patients who developed acute kidney injury within 48 hours of admission to hospital.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alexandria University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Mamdouh Mahmoud Mohamed Elsayed , MD

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hala S ElWakil, MD

Role: PRINCIPAL_INVESTIGATOR

professor

yasmine s naga, MD

Role: STUDY_CHAIR

ASS. prof

Mohamed mamdouh Elsayed, MD

Role: STUDY_CHAIR

Lecturer

sara R Nagib, MBBCh

Role: STUDY_CHAIR

Resident

Locations

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Faculty of Medicine, Aexandria University

Alexandria, , Egypt

Site Status

Countries

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Egypt

References

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Singh TB, Rathore SS, Choudhury TA, Shukla VK, Singh DK, Prakash J. Hospital-acquired acute kidney injury in medical, surgical, and intensive care unit: A comparative study. Indian J Nephrol. 2013 Jan;23(1):24-9. doi: 10.4103/0971-4065.107192.

Reference Type BACKGROUND
PMID: 23580801 (View on PubMed)

Sawhney S, Mitchell M, Marks A, Fluck N, Black C. Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review. BMJ Open. 2015 Jan 6;5(1):e006497. doi: 10.1136/bmjopen-2014-006497.

Reference Type BACKGROUND
PMID: 25564144 (View on PubMed)

Hsu CN, Lee CT, Su CH, Wang YL, Chen HL, Chuang JH, Tain YL. Incidence, Outcomes, and Risk Factors of Community-Acquired and Hospital-Acquired Acute Kidney Injury: A Retrospective Cohort Study. Medicine (Baltimore). 2016 May;95(19):e3674. doi: 10.1097/MD.0000000000003674.

Reference Type BACKGROUND
PMID: 27175701 (View on PubMed)

Ponce D, Balbi A. Acute kidney injury: risk factors and management challenges in developing countries. Int J Nephrol Renovasc Dis. 2016 Aug 22;9:193-200. doi: 10.2147/IJNRD.S104209. eCollection 2016.

Reference Type BACKGROUND
PMID: 27578995 (View on PubMed)

Other Identifiers

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Hospiat Acq. AKI

Identifier Type: -

Identifier Source: org_study_id

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