Medtronic SYMBIOSIS Post-Market Registry for Patients Undergoing Cardiac Surgery

NCT ID: NCT04241328

Last Updated: 2025-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-09

Study Completion Date

2026-12-31

Brief Summary

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The purpose of this observational, multi-center prospective, post-market registry is to confirm real-world device safety and performance, to ensure the continued acceptability of identified risks, and detect emerging risks.

Detailed Description

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The objective is to collect product safety and performance data for Medtronic CE (Conformitè Europëenne )-Marked Cardiac Surgery, including perfusion (CS) products.

The main goals of this data collection are as follows:

* Identification of any (new) device-related complications including events which were not anticipated or documented in the Instructions For Use (IFU), or Risk Management Plan, or Clinical Evidence Evaluation report, or Design Failure Modes and Effect Analysis
* Evaluation of device success defined as the absence of any probable or causal device-related adverse events or device deficiencies
* Evaluation of general device performance when applicable

Subjects are enrolled and, if applicable, followed according to routine care practices at their treating hospital.

Inclusion Criteria:

* Subject or legally authorized representative provides written data release and/or informed consent per institution and/or geographical requirements prior to discharge from participating Registry hospital.
* Subject will undergo or underwent a procedure in which an eligible Medtronic CS product is/was used.

Exclusion Criteria:

• Currently participating in an interventional drug or device study which may induce confounding factor(s) to the results from this Registry

Data collection includes, for example:

* Demographics
* Product performance information
* Safety Events

Conditions

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Cardiovascular Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Subject or legally authorized representative provides written data release and/or informed consent per institution and/or geographical requirements prior to discharge from participating registry hospital.
* Subject will undergo or underwent a procedure in which an eligible Medtronic CS product is/was used.

Exclusion Criteria

* Currently participating in an interventional drug or device study which may induce confounding factor(s) to the results from this Registry
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiac Surgery

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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AKH Wien

Vienna, , Austria

Site Status RECRUITING

Ziekenhuis Oost-Limburg

Genk, , Belgium

Site Status RECRUITING

UZ Leuven

Leuven, , Belgium

Site Status RECRUITING

CHU d'Angers

Angers, , France

Site Status COMPLETED

Clinique Claude Bernard

Metz, , France

Site Status TERMINATED

Uniklinik RWTH Aachen

Aachen, , Germany

Site Status RECRUITING

Herz- und Diabeteszentrum NRW

Bad Oeynhausen, , Germany

Site Status RECRUITING

Deutsches Herzzentrum München

Munich, , Germany

Site Status RECRUITING

Onassis Hospital

Athens, , Greece

Site Status ACTIVE_NOT_RECRUITING

Catharina Ziekenhuis

Eindhoven, , Netherlands

Site Status COMPLETED

Maastricht University Medical Center (MUMC+)

Maastricht, , Netherlands

Site Status ACTIVE_NOT_RECRUITING

St. Antonius Ziekenhuis

Nieuwegein, , Netherlands

Site Status RECRUITING

Haukeland Universitetssjukehus

Bergen, , Norway

Site Status RECRUITING

Hospital Clinic Barcelona

Barcelona, , Spain

Site Status COMPLETED

Countries

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Austria Belgium France Germany Greece Netherlands Norway Spain

Central Contacts

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Lisa Lindelauf, BSc

Role: CONTACT

+31611605434

Facility Contacts

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D Wiedemann, Prof. Dr.

Role: primary

Christiaan van Kerrebroeck, Dr.

Role: primary

Wouter Oosterlinck, Doctor

Role: primary

Prof. Dr. Dodge Khatami

Role: primary

Jan Gummert, Professor

Role: primary

Keti Vitanova, Dr. med.

Role: primary

Dr. Bart van Putte

Role: primary

Rune Haaverstad, Professor

Role: primary

Other Identifiers

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MDT19022PMF001

Identifier Type: -

Identifier Source: org_study_id

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