Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.

NCT ID: NCT04215263

Last Updated: 2020-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

109 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-01

Study Completion Date

2019-07-05

Brief Summary

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The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery.

Detailed Description

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The study was a prospective cohort study, assessing the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery. The study used cognitive tests such as RAVLT, TMT, and Digit span tests. POCD definition is reduction in postoperative cognitive function by as much as 20% at a minimum of 2 cognitive tests.

Conditions

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Undergoing General Anaesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Geriatric patient underwent general anesthesia procedure

geriatric patients (≥60 years) ware assessed for cognitive impairment after general anesthesia for non-neurologic noncardiac surgery.

Questionaire

Intervention Type OTHER

Patient was assessed using mini international neuropsychiatric interview

Interventions

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Questionaire

Patient was assessed using mini international neuropsychiatric interview

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia
* patient can do reading and writing
* patient can speak in Bahasa
* signing informed consent

Exclusion Criteria

* patient with cognitive impairment or psychiatric disorder such as delirium, amnesia, anxiety disorder, or depression.
* patient under psychotropic drugs or narcotics.
* patient with history of brain tumor, head injury or motoric disturbance and disability that can disturbed neurocognitive test
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Indonesia University

OTHER

Sponsor Role lead

Responsible Party

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Aries Perdana

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aries Perdana, MD

Role: PRINCIPAL_INVESTIGATOR

Indonesia University

Locations

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Indonesia University

Jakarta, DKI Jakarta, Indonesia

Site Status

Countries

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Indonesia

References

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BEDFORD PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955 Aug 6;269(6884):259-63. doi: 10.1016/s0140-6736(55)92689-1. No abstract available.

Reference Type RESULT
PMID: 13243706 (View on PubMed)

Strom C, Rasmussen LS, Sieber FE. Should general anaesthesia be avoided in the elderly? Anaesthesia. 2014 Jan;69 Suppl 1(Suppl 1):35-44. doi: 10.1111/anae.12493.

Reference Type RESULT
PMID: 24303859 (View on PubMed)

Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014 Feb 21;111(8):119-25. doi: 10.3238/arztebl.2014.0119.

Reference Type RESULT
PMID: 24622758 (View on PubMed)

Canet J, Raeder J, Rasmussen LS, Enlund M, Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C, Abildstrom H, Sneyd JR, Vila P, Johnson T, Munoz Corsini L, Silverstein JH, Nielsen IK, Moller JT; ISPOCD2 investigators. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiol Scand. 2003 Nov;47(10):1204-10. doi: 10.1046/j.1399-6576.2003.00238.x.

Reference Type RESULT
PMID: 14616316 (View on PubMed)

van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012 Mar;67(3):280-93. doi: 10.1111/j.1365-2044.2011.07008.x.

Reference Type RESULT
PMID: 22321085 (View on PubMed)

Other Identifiers

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IndonesiaUAnes 044

Identifier Type: -

Identifier Source: org_study_id

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