Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-21

Study Completion Date

2021-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine what percentage of patients have cognitive problems (for example, memory or concentration difficulties) after surgery and anesthesia, what the characteristics of these problems are, and whether they persist over time. In particular, the investigators want to study this in the French-speaking Quebec population with cognitive evaluation tools adapted for this population.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Postoperative Cognitive Dysfunction in Elderly

NCT02068742

Postoperative Cognitive Dysfunction

UNKNOWN NA

Post Operative Cognitive Dysfunction

NCT03067259

Postoperative Complications

COMPLETED NA

Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment

NCT07135336

Cognitive and Behavioral Impairment

RECRUITING

Postoperative Cognitive Dysfunction in Geriatric Patients

NCT00512200

Delirium, Dementia, Amnestic, Cognitive Disorders Postoperative Complications Memory Disorders

COMPLETED

Patients Experiences of Early Postoperative Cognition

NCT05361460

Postoperative Cognitive Decline Biomarkers Postoperative Recovery +1 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Multiple experimental and observational studies have established that a non-negligible percentage of individuals undergoing surgery and anesthesia will experience a postoperative decline in mental abilities. These cognitive changes can range from postoperative delirium to more subtle and longer lasting (weeks to months) impairments; these latter changes are often referred to in the literature as postoperative cognitive dysfunction (POCD). While the precise causes of POCD remain nebulous, a clear epidemiological risk factor is advanced age - a demographic group that accounts for an increasing percentage of elective surgeries in North America. Several RCTs have attempted to link specific aspects of anesthesia, such as depth of anesthesia, regional vs general anesthesia, hemodynamic parameters, specific anesthetic agents, etc., to the risk of developing POCD in both the elderly and general populations. Results have often been conflicting and, based on current evidence, it is difficult to identify any specific anesthetic strategy that clearly reduces the risk of POCD. The present study aims to establish the incidence and neuropsychological characteristics of POCD in the investigator's local patient population as well as to establish the feasibility of pre- and postoperative cognitive testing with assessment tools adapted to and validated for Quebec francophones in order to lay the groundwork for future studies by the research group of interventions targeting specific anesthetic techniques and monitoring modalities.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Delirium Cognitive Impairment Cognitive Decline Cognitive Change Postoperative Cognitive Dysfunction Postoperative Delirium

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Observational cohort

Adults 70 years of age or older undergoing major noncardiac surgery under protocolized general anesthesia

Protocolized general anesthesia

Intervention Type PROCEDURE

Induction and maintenance of general anesthesia, post-operative analgesia with protocolized drugs and doses. Maintenance of MAP +/- 20% of baseline with vasopressors as needed.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Protocolized general anesthesia

Induction and maintenance of general anesthesia, post-operative analgesia with protocolized drugs and doses. Maintenance of MAP +/- 20% of baseline with vasopressors as needed.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 70 years of age or older
* Undergoing elective abdominal, gynecological, or urological surgery requiring post-operative hospitalization and with an expected anesthesia time of 60 minutes or more
* Seen in pre-operative clinic of Maisonneuve-Rosemont hospital

Exclusion Criteria

* Known dementia or other cognitive impairment
* Psychiatric disease
* Significant hearing or vision impairment
* Inability to communicate in French
* Allergy or other contraindication to medications in standardized anesthesia protocol

Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No