Effect of Smoking on Saliva Composition and the Development of Dental Erosion
NCT ID: NCT04208802
Last Updated: 2026-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2020-09-24
2022-07-29
Brief Summary
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Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured.
Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Smokers
Volunteers smoking at least 10 cigarettes per day
Use of fluoridated toothpaste
Use of fluoridated toothpaste
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with resin samples
Wearing of an intraoral device with resin samples
Non-smokers
Non-smoking volunteers
Use of fluoridated toothpaste
Use of fluoridated toothpaste
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with resin samples
Wearing of an intraoral device with resin samples
Interventions
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Use of fluoridated toothpaste
Use of fluoridated toothpaste
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with bovine tooth samples
Wearing of an intraoral device with resin samples
Wearing of an intraoral device with resin samples
Eligibility Criteria
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Inclusion Criteria
* Intake of medications or diseases altering salivary secretion
* Refusal to use fluoridated toothpastes
* Known allergies to substances used in the study
* Orthodontic treatment or malfunction which does not allow wearing an intraoral device
20 Years
50 Years
ALL
Yes
Sponsors
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University of Göttingen
OTHER
Responsible Party
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Philipp Kanzow, Prof. Dr. med. dent., Dr. rer. medic.
Senior Dental Practitioner
Principal Investigators
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Annette Wiegand, Prof. Dr. med. dent.
Role: PRINCIPAL_INVESTIGATOR
Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany
Locations
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University Medical Center Göttingen, Dept. of Preventive Dentistry, Periodontology and Cariology
Göttingen, Lower Saxony, Germany
Countries
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References
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Carpenter G, Cotroneo E, Moazzez R, Rojas-Serrano M, Donaldson N, Austin R, Zaidel L, Bartlett D, Proctor G. Composition of enamel pellicle from dental erosion patients. Caries Res. 2014;48(5):361-7. doi: 10.1159/000356973. Epub 2014 Mar 6.
Moazzez R, Bartlett D. Intrinsic causes of erosion. Monogr Oral Sci. 2014;25:180-96. doi: 10.1159/000360369. Epub 2014 Jun 26.
Wiegand A, Bliggenstorfer S, Magalhaes AC, Sener B, Attin T. Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids. Acta Odontol Scand. 2008 Aug;66(4):225-30. doi: 10.1080/00016350802183401.
Wiegand A, Meier W, Sutter E, Magalhaes AC, Becker K, Roos M, Attin T. Protective effect of different tetrafluorides on erosion of pellicle-free and pellicle-covered enamel and dentine. Caries Res. 2008;42(4):247-54. doi: 10.1159/000135669. Epub 2008 Jun 4.
Zwier N, Huysmans MC, Jager DH, Ruben J, Bronkhorst EM, Truin GJ. Saliva parameters and erosive wear in adolescents. Caries Res. 2013;47(6):548-52. doi: 10.1159/000350361. Epub 2013 Jun 15.
Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625.
Wiegand A, Rosemann A, Hoch M, Barke S, Dakna M, Kanzow P. Erosion-Protective Capacity of the Salivary Pellicle of Female and Male Subjects Is Not Different. Caries Res. 2019;53(6):636-642. doi: 10.1159/000500046. Epub 2019 Jun 4.
Kanzow P, Lenz C, Schlarmann F, Barke S, Rohland B, Schmidt A, Gorshkova A, Neuenroth L, Wiegand A. Saliva and salivary pellicle composition and proteomic profile in smokers vs. non-smokers and its effect on dental erosion. J Dent. 2026 Jan 21:106517. doi: 10.1016/j.jdent.2026.106517. Online ahead of print.
Other Identifiers
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Erosion-Smoking
Identifier Type: -
Identifier Source: org_study_id
15/10/19
Identifier Type: OTHER
Identifier Source: secondary_id
02785
Identifier Type: OTHER
Identifier Source: secondary_id
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