Ghrelin Levels in Patients With Protein C Deficiency

NCT ID: NCT04180657

Last Updated: 2019-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-31

Study Completion Date

2020-07-31

Brief Summary

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In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.

30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.

If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.

Detailed Description

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Conditions

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Protein C Deficiency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with protein C deficiency

Patient and control group are compared regarding ghrelin, growth hormone levels and appetite, and no other intervention is made.

Protein C deficiency

Intervention Type GENETIC

The effect of protein C deficiency on ghrelin levels are investigated.

Healthy controls

Patient and control group are compared regarding ghrelin, growth hormone levels and appetite, and no other intervention is made.

No interventions assigned to this group

Interventions

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Protein C deficiency

The effect of protein C deficiency on ghrelin levels are investigated.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* protein C deficiency or healthy subjects
* age 18-70
* BMI 18-35
* written statement to join the study

Exclusion Criteria

* chronic illness, apart from protein C deficiency and lifestyle diseases
* everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.
* blood donation within three months prior to the investigation.
* Alcohol abuse
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Sascha S Horup, MD

Role: CONTACT

+45 27149089

Rakel F Johansen, MD

Role: CONTACT

Other Identifiers

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69965

Identifier Type: -

Identifier Source: org_study_id

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