Evaluation of the Efficacy and Safety of Lacosamide in Pediatric Patients With Epilepsy

NCT ID: NCT04144218

Last Updated: 2020-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-08

Study Completion Date

2021-12-31

Brief Summary

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Children with focal refractory epilepsy will be routinely included in the collection of history, blood routine, biochemistry, EEG, MRI and 18F-FDG PET to determine the location of the epileptogenic focus and to assess the severity of the disease. This international multicenter clinical trial uses a double-blind, randomized, controlled study to evaluate the safety and efficacy of LCM in clinical applications in children with epilepsy.

Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Control group

Group Type PLACEBO_COMPARATOR

Placebo oral tablet

Intervention Type DRUG

The control group will be given oral placebo supplementation on the basis of the original antiepileptic drugs.

Experimental group

Group Type EXPERIMENTAL

Lacosamide

Intervention Type DRUG

The experimental group will be given oral lacosamide supplementation on the basis of the original antiepileptic drugs.

Interventions

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Lacosamide

The experimental group will be given oral lacosamide supplementation on the basis of the original antiepileptic drugs.

Intervention Type DRUG

Placebo oral tablet

The control group will be given oral placebo supplementation on the basis of the original antiepileptic drugs.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of focal epilepsy with or without generalized seizures according to the 2017 International Association of Anti-Epilepsy (ILAE) classification criteria.
* Stable taking 1 or 2 other first-line anti-epileptic drugs for at least 10 weeks before screening visits.
* Seizure occurred during the 8-week retrospective baseline period with a complete medical record diary.

Exclusion Criteria

* A history of status epilepticus within 3 months prior to screening visits.
* Poor adherence to previous treatment.
* Other serious organic diseases, mental illnesses and neurological diseases.
* Abnormal liver and kidney function and blood routine results.
Minimum Eligible Age

4 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tongji Hospital

OTHER

Sponsor Role collaborator

Michigan State University

OTHER

Sponsor Role collaborator

Juntendo University

OTHER

Sponsor Role collaborator

Technical University of Munich

OTHER

Sponsor Role collaborator

RIKEN

OTHER

Sponsor Role collaborator

University of California, Los Angeles

OTHER

Sponsor Role collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jing Wang

Role: CONTACT

+86 057187767138

Facility Contacts

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Jing Wang

Role: primary

+86 057187767138

Other Identifiers

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IR20191016

Identifier Type: -

Identifier Source: org_study_id

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