To Determine Tolerability and Efficacy of Long-term Oral Lacosamide in Patients With Partial Seizures

NCT ID: NCT00552305

Last Updated: 2018-07-17

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

370 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-08-31

Study Completion Date

2010-02-28

Brief Summary

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The purpose of this trial is to determine whether lacosamide is safe and effective for long-term use in patients with partial-seizures from epilepsy.

Detailed Description

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Conditions

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Partial Epilepsies

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Lacosamide

50mg and 100mg tablets up to 800 mg/day as twice a day (BID) dosing

Group Type EXPERIMENTAL

lacosamide

Intervention Type DRUG

50mg and 100mg tablets up to 800 mg/day as twice a day (BID) dosing throughout the trial

Interventions

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lacosamide

50mg and 100mg tablets up to 800 mg/day as twice a day (BID) dosing throughout the trial

Intervention Type DRUG

Other Intervention Names

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Vimpat

Eligibility Criteria

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Inclusion Criteria

* Completion of parent clinical trial for treatment of partial seizures.

Exclusion Criteria

* Receiving any study drug or experimental device other than lacosamide.
* Meets withdrawal criteria for parent trial or experiencing ongoing serious adverse event.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493 (UCB)

Locations

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Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Los Angeles, California, United States

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Englewood, Colorado, United States

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Gainesville, Florida, United States

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Hollywood, Florida, United States

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Miami, Florida, United States

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Ponte Vedra Beach, Florida, United States

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Chicago, Illinois, United States

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Springfield, Illinois, United States

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Indianapolis, Indiana, United States

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Iowa City, Iowa, United States

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Wichita, Kansas, United States

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Crestview Hills, Kentucky, United States

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Lexington, Kentucky, United States

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Baltimore, Maryland, United States

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Frederick, Maryland, United States

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Boston, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Detroit, Michigan, United States

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Saint Paul, Minnesota, United States

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Chesterfield, Missouri, United States

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St Louis, Missouri, United States

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Somerset, New Jersey, United States

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New York, New York, United States

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Durham, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Hershey, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Irving, Texas, United States

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Lubbock, Texas, United States

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Wichita Falls, Texas, United States

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Bennington, Vermont, United States

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Charlottesville, Virginia, United States

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Marshfield, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Bonn, , Germany

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Erlangen, , Germany

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Kehl Kork, , Germany

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Schwalmstedt-Treysa, , Germany

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Budapest, , Hungary

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Zalaegerszeg, , Hungary

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Kaunas, , Lithuania

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Vilnius, , Lithuania

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Poznan, , Poland

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Gothenburg, , Sweden

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Stockholm, , Sweden

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Bern/Biel, , Switzerland

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Zurich, , Switzerland

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Bucks/London, , United Kingdom

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Glasgow, , United Kingdom

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Liverpool, , United Kingdom

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Countries

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United States Germany Hungary Lithuania Poland Sweden Switzerland United Kingdom

References

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Rosenfeld W, Fountain NB, Kaubrys G, Ben-Menachem E, McShea C, Isojarvi J, Doty P; SP615 Study Investigators. Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8 years. Epilepsy Behav. 2014 Dec;41:164-70. doi: 10.1016/j.yebeh.2014.09.074. Epub 2014 Oct 27.

Reference Type DERIVED
PMID: 25461210 (View on PubMed)

Related Links

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Other Identifiers

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SP0615

Identifier Type: -

Identifier Source: org_study_id

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