Assess Safety and Efficacy of Lacosamide in Patients With Partial Seizures

NCT ID: NCT00515619

Last Updated: 2017-08-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

376 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-12-31

Study Completion Date

2010-08-31

Brief Summary

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The main purpose of this trial is to determine safety and efficacy of Lacosamide under long term therapy.

Detailed Description

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Conditions

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Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Lacosamide

50 mg and 100 mg tablets up to 800 mg/day as twice day (BID) dosing

Group Type EXPERIMENTAL

Lacosamide

Intervention Type DRUG

50 mg and 100 mg tablets up to 800 mg/day as twice day (BID) dosing throughout the trial

Interventions

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Lacosamide

50 mg and 100 mg tablets up to 800 mg/day as twice day (BID) dosing throughout the trial

Intervention Type DRUG

Other Intervention Names

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SPM 927 LCM

Eligibility Criteria

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Inclusion Criteria

* diagnosis of Epilepsy
* completion of double blind trial

Exclusion Criteria

* taking other investigational drug than Lacosamide
* meeting withdrawal criteria from double blind trial
Minimum Eligible Age

16 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493

Locations

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Randwick, New South Wales, Australia

Site Status

Maroochydore, Queensland, Australia

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Woodville, South Australia, Australia

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Clayton, Victoria, Australia

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Parkville, Victoria, Australia

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West Heidelberg, Victoria, Australia

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Adelaide, , Australia

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Zagreb, , Croatia

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Brno, , Czechia

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Hradec Králové, , Czechia

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Olomouc, , Czechia

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Ostrava-Trebovice, , Czechia

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Pilsen, , Czechia

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Prague, , Czechia

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Helsinki, , Finland

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Kuopio, , Finland

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Oulu, , Finland

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Tampere, , Finland

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Lille, , France

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Lyon, , France

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Montpellier, , France

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Paris, , France

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Toulouse, , France

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Berlin, , Germany

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Erlangen, , Germany

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Göttingen, , Germany

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Marburg, , Germany

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München, , Germany

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Ulm, , Germany

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Budapest, , Hungary

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Pécs, , Hungary

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Szeged, , Hungary

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Szombathely, , Hungary

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Kaunas, , Lithuania

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Vilnius, , Lithuania

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Bialystok, , Poland

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Gdansk, , Poland

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Krakow, , Poland

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Warsaw, , Poland

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Moscow, , Russia

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Saint Petersburg, , Russia

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Girona, , Spain

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Granada, , Spain

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Madrid, , Spain

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Zaragoza, , Spain

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Gothenburg, , Sweden

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Linköping, , Sweden

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Stockholm, , Sweden

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Cardiff, , United Kingdom

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Dundee, , United Kingdom

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Glasgow, , United Kingdom

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London, , United Kingdom

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Salford, , United Kingdom

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Swansea, , United Kingdom

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Countries

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Australia Croatia Czechia Finland France Germany Hungary Lithuania Poland Russia Spain Sweden United Kingdom

References

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Borghs S, de la Loge C, Brabant Y, Cramer J. Sensitivity testing of the Seizure Severity Questionnaire (SSQ). Epilepsy Behav. 2014 Feb;31:281-5. doi: 10.1016/j.yebeh.2013.10.010. Epub 2013 Nov 22.

Reference Type RESULT
PMID: 24275520 (View on PubMed)

Rosenow F, Kelemen A, Ben-Menachem E, McShea C, Isojarvi J, Doty P; SP774 study investigators. Long-term adjunctive lacosamide treatment in patients with partial-onset seizures. Acta Neurol Scand. 2016 Feb;133(2):136-144. doi: 10.1111/ane.12451. Epub 2015 Jul 2.

Reference Type DERIVED
PMID: 26133811 (View on PubMed)

Related Links

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Other Identifiers

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2004-000152-16

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

SP0774

Identifier Type: -

Identifier Source: org_study_id

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