Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
NCT ID: NCT04125576
Last Updated: 2019-11-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2019-10-25
2019-12-20
Brief Summary
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Detailed Description
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To study changes in the pain network associated with neuropathic pain, magnetic resonance imaging(MRI) will be used to evaluate cerebral blood volume(CBV) in patients who was injuried by burn. Over the fifty participants will be recruited. The participants will be comprised 30 subjects with neuropathic pain caused by thermal injury and 20 healthy contols. The 30 patients with neuropathic pain will be comprised divided into 15 electrical injury group and 15 non-electrical burn injury group. The patients are included the patients with severe neuropathic pain that is rated at least 5 on the visual analogue scale (VAS), despite treatments with gabapentin medication and other physical modalities. The intensity of neuropathic pain will be measured using the visual analogue scale(VAS). Depressive mood will be assessed using the Beck Depression Scale. CBV maps will be compared between burn patients and controls. And the relationship between individual participant CBV(measured in voxels), BDS and VAS score will be also examined.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Burn patients
The subjects complaine of severe neuropathic pain that is rated at least 5 on the visual analogue scale (VAS), despite treatments with gabapentin medication and other physical modalities.
magnetic resonance imaging(MRI)
magnetic resonance imaging(MRI) will be used to evaluate cerebral blood volume(CBV) of pain network
Healthy controls
age and sex matched healthy controls
magnetic resonance imaging(MRI)
magnetic resonance imaging(MRI) will be used to evaluate cerebral blood volume(CBV) of pain network
Interventions
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magnetic resonance imaging(MRI)
magnetic resonance imaging(MRI) will be used to evaluate cerebral blood volume(CBV) of pain network
Eligibility Criteria
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Inclusion Criteria
* severe neuropatic pain rated at least 5 on the 10-point numerical rating scale (NRS).
Exclusion Criteria
* history of neurologic disease or brain surgery
* unstable heart disease or presence of a cardiac pacemaker
* psychiatric disorder
* diabetes mellitus
* abnormal renal function
* contraindication for MRI
* pregnancy.
18 Years
60 Years
ALL
Yes
Sponsors
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National Research Foundation of Korea
OTHER
Hangang Sacred Heart Hospital
OTHER
Responsible Party
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Locations
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Hangang Sacred Heart Hospital
Seoul, Yeong-deungpo-Dong, South Korea
Countries
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Central Contacts
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Facility Contacts
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References
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Park CH, Seo CH, Jung MH, Joo SY, Jang S, Lee HY, Ohn SH. Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury. Neuroradiology. 2017 Sep;59(9):915-921. doi: 10.1007/s00234-017-1876-1. Epub 2017 Jul 8.
Seo CH, Park CH, Jung MH, Jang S, Joo SY, Kang Y, Ohn SH. Preliminary Investigation of Pain-Related Changes in Cerebral Blood Volume in Patients With Phantom Limb Pain. Arch Phys Med Rehabil. 2017 Nov;98(11):2206-2212. doi: 10.1016/j.apmr.2017.03.010. Epub 2017 Apr 6.
Other Identifiers
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HangangSHH-5
Identifier Type: -
Identifier Source: org_study_id
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