Magnetic Resonance Imaging in Patients with Trigeminal Neuralgia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-10

Study Completion Date

2026-03-30

Brief Summary

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This study intends to use MRI technology to analyze the dynamic changes and microstructure changes of the brain network in patients with trigeminal neuralgia, evaluate the blood-brain barrier and water exchange rate, and further analyze their correlation with clinical indicators, so as to explore the changes in brain structural plasticity and potential neural mechanisms

Detailed Description

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Conditions

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Trigeminal Neuralgia (TN)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Trigeminal Neuralgia Group

Patients who were diagnosed with trigeminal neuralgia (TN) according to the International Classification of Headache Disorders (ICHD) and were intolerant or ineffective to the preoperative treatment of carbamazepine or ocasepine, requiring the treatment of percutaneous balloon compression (PBC)

No interventions assigned to this group

Health Control Group

Healthy controls matched by age, sex, etc

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* The diagnosis was TN according to the ICHD.
* Patients requiring surgical treatment due to ineffective or intolerant treatment with carbamazepine or oxasepine before operation;
* First surgical treatment;
* Right-handed dominant;
* There was no significant loss of sensation

Exclusion Criteria

* Secondary TN;
* Associated with other types of chronic pain or neuropsychiatric disorders;
* History of head trauma or stroke or cerebrovascular ischemia;
* History of microvascular decompression or other treatments (gamma knife radiosurgery, etc.);
* Unable to cooperate independently;
* Contraindications, such as uncontrolled infection, coagulopathy, etc.;
* MRIcontraindications (e.g., pacemaker, claustrophobia, etc.)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Feng Gao

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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2024S240

Identifier Type: -

Identifier Source: org_study_id