Exploring the Effects of Obesity and Bariatric Surgery on the Brain Using Magnetic Resonance Imaging
NCT ID: NCT06708117
Last Updated: 2024-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
260 participants
OBSERVATIONAL
2025-01-01
2030-12-31
Brief Summary
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The causes of obesity are highly complex, with eating behaviors playing a crucial role. Current research indicates that many brain regions are involved in the regulation of appetite, eating behaviors, and obesity, but the detailed mechanisms remain unclear. Bariatric surgery has been shown to effectively achieve long-term weight loss and improve obesity-related conditions in severely obese patients, making it a valuable research platform for obesity treatment. Recent studies have found that after bariatric surgery, patients experience reduced hunger, increased satiety, and altered responses and preferences for food stimuli. Magnetic resonance imaging (MRI) is a widely used tool for analyzing brain structure and functional changes. Recent imaging studies have demonstrated changes in brain structure and connectivity across multiple regions after bariatric surgery. However, due to the complexity of brain structure and these changes, many questions remain unanswered. This study aims to investigate the effects of obesity and bariatric surgery on brain structure and function using MRI, to identify potential mechanisms for treating obesity.
Methods:
This study plans to recruit 200 obese patients aged 20 years or older who are scheduled to undergo bariatric surgery within a 5-year period. Participants will undergo brain MRI scans before and six months after surgery. At these two time points, they will also complete the Dutch Eating Behavior Questionnaire (DEBQ) to assess changes in eating behaviors and provide blood samples for the analysis of gastrointestinal, obesity-related, and appetite-related hormones. Additionally, 60 healthy individuals with normal weight will be recruited as a control group to undergo the same brain MRI scans, DEBQ assessments, and blood analyses. This control group will help explore the effects of obesity and bariatric surgery on brain structure and function.
Expected Results:
This study is expected to reveal the structural and functional changes in brain MRI associated with obesity and bariatric surgery, providing insights into potential mechanisms for treating obesity.
Detailed Description
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B. Healthy Normal-Weight Participants Healthy participants will be recruited via promotional materials distributed within NTUH and online. Physicians and research staff will explain the study procedures to the participants.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) ≥ 37.5, or BMI ≥ 27 with obesity-related comorbidities such as type 2 diabetes, hypertension, or obstructive sleep apnea.
* Scheduled to undergo bariatric surgery for obesity treatment.
* Aged 20 to 65 years.
* BMI between 18.5 and 24.
Exclusion Criteria
* Use of neurological or psychiatric medications.
* Diagnosis of cancer or major gastrointestinal diseases.
* History of major abdominal surgery.
* Presence of metallic implants in the body.
* Claustrophobia.
* Currently pregnant.
B. Healthy Normal-Weight Participants
* Presence of neurological or psychiatric disorders.
* Use of neurological or psychiatric medications.
* Diagnosis of cancer or major gastrointestinal diseases.
* History of major abdominal surgery.
* Presence of metallic implants in the body.
* Claustrophobia.
* Currently pregnant.
20 Years
ALL
Yes
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Po-Jen Yang, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
National Taiwan University Hospital
Central Contacts
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Other Identifiers
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202406090RINA
Identifier Type: -
Identifier Source: org_study_id