Mitochondrial Remodeling After Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-23

Study Completion Date

2022-12-03

Brief Summary

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Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

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Detailed Description

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Conditions

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Overweight and Obesity Insulin Resistance Metabolic Disease Mitochondrial Metabolism Sedentary Lifestyle

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Participants will be asked to complete 2 screening visits to determine eligibility. If participants remain eligible, they will be asked to complete 2 metabolic study visits, 1 before and 1 after 2 weeks of supervised exercise training on a stationary bike.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Pre-training Metabolic Study Visit

Participants will first complete a pre-training metabolic study visit.

Group Type NO_INTERVENTION

No interventions assigned to this group

Post-training Metabolic Study Visit

Participants will complete a second, identical metabolic study visit following 2-weeks of exercise training.

Group Type EXPERIMENTAL

Short-term Exercise Training

Intervention Type BEHAVIORAL

Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Interventions

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Short-term Exercise Training

Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age 18-45 years
* Body mass index (BMI) 18-45 kg/m2
* Sedentary (\<1 hour of planned exercise per week)

Exclusion Criteria

* Regular exercise (\>1 hour of planned exercise per week)
* Smoking, tobacco or nicotine use within the last 1-year
* Fasting glucose \>126mg/dL
* Hypertension (systolic pressure \>140 mmHg or diastolic pressure \>90 mmHg)
* Chronic metabolic or cardiovascular health conditions
* Pregnant, nursing, irregular menses or post-menopausal
* Lidocaine allergy
* Certain medications
* Physical limitations that prevent safe or successful exercise completion
* Diminished capacity for consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes