Exposure Of Bisphenol Analogues In Chronic Kidney Disease and Dialysis Patients

NCT ID: NCT04100421

Last Updated: 2019-09-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

154 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-01

Study Completion Date

2018-06-30

Brief Summary

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In this retrospective study, the serum levels of Bisphenol A (BPA) and three BPA analogs, namely, bisphenol B (BPB), bisphenol S (BPS), and bisphenol F (BPF), in patients with CKD, patients on dialysis therapy and healthy control were investigated to find out if BPA and BPA analogs accumulates in patients with chronic kidney disease (CKD), and if hemodialysis filters contribute to bisphenol burden in patients on hemodialysis (HD).

Detailed Description

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Conditions

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Chronic Kidney Diseases Hemodialysis Complication

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Mild renal injury

CKD patients with eGFR ≥ 60 ml∙min-1∙ (1.73 m2)-1. The eGFR was evaluated by the Chronic Kidney Disease Epidemiology Collaboration (eGFR-EPI).

No interventions assigned to this group

Moderate renal injury

CKD patients with eGFR between 30 ml∙min-1∙(1.73 m2)-1 to 60 ml∙min-1∙(1.73 m2)-1. The eGFR was evaluated by the Chronic Kidney Disease Epidemiology Collaboration (eGFR-EPI).

No interventions assigned to this group

Severe renal injury

CKD patients with eGFR \< 30 ml∙min-1∙(1.73 m2)-1. The eGFR was evaluated by the Chronic Kidney Disease Epidemiology Collaboration (eGFR-EPI).

No interventions assigned to this group

Hemodialysis

uremic patients on hemodialysis therapy

No interventions assigned to this group

Peritoneal dialysis

uremic patients on peritoneal dialysis

No interventions assigned to this group

Healthy control

Healthy volunteers with no history of kidney diseases or any chronic diseases which may lead to renal injury.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age 18; informed consent

Exclusion Criteria

* absence of active inflammatory, infectious, malignant diseases, acute chronic kidney disease, or pregnancy at the initiation or during the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

OTHER

Sponsor Role lead

Responsible Party

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Ding Feng

Kidney internal medicine professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shanghai Ninth People's Hospital

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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BPs

Identifier Type: -

Identifier Source: org_study_id

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