Impact of Regular Low-Frequency Hemoperfusion on Medium- to Long-Term Prognosis in Maintenance Dialysis Patients

NCT ID: NCT07348913

Last Updated: 2026-01-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 879 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-01-01
• Study Completion Date: 2024-12-31

Brief Summary

Objective: To investigate the effect of regular low-frequency hemoperfusion on all-cause mortality and cardiovascular/cerebrovascular mortality risk in maintenance hemodialysis (MHD) patients.

Methods: Data from MHD patients over the past 10 years at our blood purification center were retrospectively collected. Patients were divided into a hemoperfusion group (receiving regular low-frequency hemoperfusion once monthly) and a non-hemoperfusion group. Propensity score matching (PSM) was used to balance baseline characteristics. Differences in cumulative all-cause and cardiovascular/cerebrovascular mortality between the two groups before and after matching were compared. A competing risk model was employed to analyze mortality risk.

Detailed Description

Clinical and laboratory data were collected for all enrolled patients. These included age, sex, underlying medical conditions, dialysis vintage, blood pressure, serum albumin, hemoglobin, platelet count, C-reactive protein (CRP), serum calcium, serum phosphorus, intact parathyroid hormone (iPTH), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, and serum β2-microglobulin. Time-averaged mean values were calculated for blood pressure and laboratory parameters across the entire follow-up period. Data on cardiovascular/cerebrovascular death and all-cause mortality over the past ten years were also compiled.

Given the considerably larger size of the Hemoperfusion Group compared with the Non-Hemoperfusion Group, propensity score matching (PSM) was performed by specialized statisticians during data processing to balance baseline characteristics between the two groups. This approach enabled a systematic assessment of the effect of regular low-frequency hemoperfusion on cardiovascular/cerebrovascular and all-cause mortality in MHD patients.

Conditions

Regular Low-Frequency Hemoperfusion; Medium- to Long-Term Prognosis; Maintenance Dialysis Patients; Retrospective Study

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

hemoperfusion group

receive regular low-frequency hemoperfusion once monthly

No interventions assigned to this group

non-hemoperfusion group

not receive regular low-frequency hemoperfusion once monthly

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Included patients were aged ≥18 years
• Undergo dialysis treatment three times a week (each session lasting 3-4 hours)
• Having basically complete clinical and laboratory records, and having received at least 6 months of follow-up at this center

Exclusion Criteria

• Under 18 years old
• Does not receive dialysis three times a week (each session lasts 3-4 hours)
• Does not have basic complete clinical and laboratory records, and has not been followed up at this center for at least 6 months

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yunfeng Xia

OTHER

Sponsor Role: lead

Responsible Party

Yunfeng Xia

Chief Physician of Nephrology、Clinical Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Countries

China

Other Identifiers

Chong qing Medical University

Identifier Type: -

Identifier Source: org_study_id