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Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients

NCT ID: NCT01674660

Last Updated: 2012-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-09-30

Study Completion Date

2013-03-31

Brief Summary

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The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Detailed Description

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Hemodialysis patients experience higher rates of cardiovascular morbidity and mortality than the general population and many populations with other chronic diseases. This exceptional risk is explained in part by known risk factors such as diabetes, hypertension, and other uremia-related factors, including vascular calcification and stiffness, autonomic dysfunction, and a high burden of circulating inflammatory mediators. However, additional unidentified risk factors also likely contribute to the disproportionately high prevalence of cardiovascular morbidity in hemodialysis patients. Blood pressure variability may represent one plausible cardiovascular risk factor. Data from nonuremic human populations show an association between greater blood pressure variability and cardiovascular events,nonfatal cardiovascular events,stroke,and increased left ventricular mass. There has been comparatively little work examining the causes and effects of blood pressure variability in hemodialysis populations. So the purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Conditions

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Kidney Failure, Chronic

Keywords

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hemodialysis blood pressure variability volume status

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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volume status

volume status:group1 over volume status,group2 normal volume status,group3 low volume status

No interventions assigned to this group

night blood pressure

night blood pressure：group1 nondipper,group2 dipper,group3 extreme dipper,group4 riser

No interventions assigned to this group

interdialysis weight gain

interdialysis weight gain:group1 \>5% dry weight,group2 \<5% dry weight

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age 18 years or older
* receipt of thrice-weekly in-center hemodialysis
* no anticipation of imminent(\<6 months)living related kidney transplant
* not transfer of care to a nonparticipating facility
* no dialytic modality change

Exclusion Criteria

* who missed \>2 hemodialysis treatments over 1 month
* abused drugs
* severe anemia，malnutrition，chronic atrial fibrillation
* body mass index of 40 \>kg/m2
Minimum Eligible Age

24 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Chao Yang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ma Weihua

Principal Investigater

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ma WH weihua, Master

Role: PRINCIPAL_INVESTIGATOR

Beijing Chao Yang Hospital

Locations

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Nephrology, dialysis center,Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Central Contacts

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Cui TG Taigen, Dr.

Role: CONTACT

Phone: 010-85231510

Email: [email protected]

Ma WH Weihua, Master

Role: CONTACT

Phone: 010-85231952

Email: [email protected]

Facility Contacts

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Ma WH Weihua, Master

Role: primary

Cui TG taigen, Dr.

Role: backup

Other Identifiers

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19860805

Identifier Type: REGISTRY

Identifier Source: secondary_id

BeijingCYH

Identifier Type: -

Identifier Source: org_study_id