Mycoprotein Consumption and Glucose Absorption

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-28

Study Completion Date

2019-10-16

Brief Summary

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Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Double blind crossover design

Study Groups

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Ingestion of 20g Mycoprotein Drink

Milkshake containing 20g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose

Group Type EXPERIMENTAL

Mycoprotein Ingestion

Intervention Type DIETARY_SUPPLEMENT

Ingestion of various doses of mycoprotein compared to placebo control

Ingestion of 40g Mycoprotein Drink

Milkshake containing 40g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose

Group Type EXPERIMENTAL

Mycoprotein Ingestion

Intervention Type DIETARY_SUPPLEMENT

Ingestion of various doses of mycoprotein compared to placebo control

Ingestion of Isocaloric Control Drink

Milkshake containing 250ml full-fat milk, 50g glucose, 19g dried skim milk and 9g full-fat dried milk

Group Type PLACEBO_COMPARATOR

Mycoprotein Ingestion

Intervention Type DIETARY_SUPPLEMENT

Ingestion of various doses of mycoprotein compared to placebo control

Interventions

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Mycoprotein Ingestion

Ingestion of various doses of mycoprotein compared to placebo control

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male and female
* 18-35 years of age
* Consumption of sufficient amounts of carbohydrate in the diet
* Body mass index between 18.5 and 30

Exclusion Criteria

* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes), or other form of abnormal glucose metabolism (as this will affect outcome of the study).
* Any diagnosed cardiovascular disease
* Insufficient consumption of carbohydrate in the diet
* A personal or family history of epilepsy, seizures or schizophrenia
* Known pre-existing liver disease/condition
* Allergy or intolerance to milk

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes