Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

NCT ID: NCT02455765

Last Updated: 2016-01-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-06-30
• Study Completion Date: 2015-10-31

Brief Summary

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

Detailed Description

Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.

Conditions

Metabolic Diseases

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Blinding Strategy: NONE

Study Groups

White rice control

Subjects will consume white rice as control (50g carbohydrate)

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

co-ingest low dose of amino acid

Subjects will receive 68 ml of amino acid mixture together with white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

co-ingest high dose of amino acid

Subjects will receive 136 ml of amino acid mixture together with white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

pre-load low dose15 min

Subjects will receive 68 ml of amino acid mixture 15 min before consumption of white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

pre-load low dose 30 min

Subjects will receive 68 ml of amino acid mixture 30 min before consumption of white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

pre-load high dose 15 min

Subjects will receive 136 ml of amino acid mixture 15 min before consumption of white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

pre-load high dose 30 min

Subjects will receive 136 ml of amino acid mixture 30 min before consumption of white rice

Group Type: EXPERIMENTAL

Rice and Amino Acid mixtures

Intervention Type: OTHER

Rice and amino acid mixture

Interventions

Rice and Amino Acid mixtures

Rice and amino acid mixture

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Male
• Chinese ethnicity
• Age between 21-50 years
• Body mass index (BMI) between 18-24.9 kg/m2
• Waist circumference ≤ 90 cm for men
• Normal blood pressure (<120/80 mmHg)
• Fasting blood glucose < 6 mmol/L

Exclusion Criteria

• dislike the consumption of Essence of Chicken
• participating in competitive sports
• allergic to amino acids and rice
• metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
• Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
• on prescription medication
• smokers

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Cerebos Asia Pacific Pte Ltd

UNKNOWN

Sponsor Role: collaborator

Singapore Institute of Food and Biotechnology Innovation

OTHER_GOV

Sponsor Role: lead

Responsible Party

JeyaKumar Henry

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

2014/00366

Identifier Type: -

Identifier Source: org_study_id